机构：[1]Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China临床科室心脏外科中心首都医科大学附属安贞医院[2]Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China首都医科大学附属安贞医院[3]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China临床科室心脏内科中心首都医科大学附属安贞医院[4]Department of Cardiology, the First-affiliated Hospital of Henan University of Traditional Chinese Medicine, Henan, China
Background: Endo-epicardial radiofrequency catheter ablation (RFCA) of ventricular tachycardia (VT) as a first-line strategy has been shown to improve outcomes. This study sought to evaluate the feasibility and validity of open-chest epicardial and transapical endocardial substrate ablation for VT with left ventricular aneurysm (LVA) applying to routine cardiac surgery. Methods: Porcine models of LVA with VT were developed and were divided into a study group (RFCA from the epicardium via direct-view and endocardium via transapical access) and a control group (endocardial RFCA via retrograde transaortic access). Substrate-based mapping and ablation targeting abnormal potentials were performed under thoracotomy. Outcomes, including procedural success and acute freedom from VT, were analysed. Results: Twenty-four of 35 (68.57%) acute myocardial infarction (AMI) pigs developed LVA with VT in a 6-week survival period and were randomly divided into a study group (n=12) and a control group (n=12). All animals in the study group successfully underwent endocardial mapping and ablation by transapical access. The scar size of the endocardium and the left ventricular chamber volume were similar in the two groups. Acute freedom from VT in the study group was remarkably superior to that in the control group (88.33% vs. 58.33%, p=0.04). Conclusions: Combined, direct epicardial and transapical endocardial substrate mapping and ablation appeared to be feasible and effective for treating VT with LVA under thoracotomy.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81370436]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|4 区心脏和心血管系统4 区外周血管病
最新[2023]版：
大类|4 区医学
小类|4 区心脏和心血管系统4 区外周血管病
JCR分区：
出版当年[2017]版：
Q4PERIPHERAL VASCULAR DISEASEQ4CARDIAC & CARDIOVASCULAR SYSTEMS
第一作者机构：[1]Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China[2]Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China
通讯作者：
通讯机构：[1]Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China[2]Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China[*1]Department of Cardiac Surgery, Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Diseases, Capital Medical University, Anzhen Street No. 2 Chaoyang District, Beijing, 100029, China.
推荐引用方式(GB/T 7714)：
Bo Li ,Changcheng Liu ,Liangshan Wang ,et al.Open chest epicardial and transapical endocardial substrate ablation for ventricular tachycardia with left ventricular aneurysm in a porcine model[J].PERFUSION-UK.2019,34(2):154-163.doi:10.1177/0267659118814689.
APA：
Bo Li,,Changcheng Liu,,Liangshan Wang,,Jin Wang,,Yucai Hu&Chengxiong Gu.(2019).Open chest epicardial and transapical endocardial substrate ablation for ventricular tachycardia with left ventricular aneurysm in a porcine model.PERFUSION-UK,34,(2)
MLA：
Bo Li,,et al."Open chest epicardial and transapical endocardial substrate ablation for ventricular tachycardia with left ventricular aneurysm in a porcine model".PERFUSION-UK 34..2(2019):154-163
