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The design of Janus black phosphorus quantum dots@metal-organic nanoparticles for simultaneously enhancing environmental stability and photodynamic therapy efficiency

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机构： [a]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China. [b]Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China [c]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, P. R. China [d]Liver Disease Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, P. R. China. [e]Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, P. R. China

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Although newly-developed black phosphorus quantum dots (BPQDs) with unique photocatalytic properties have attracted much attention for biomedical applications, especially phototherapy, the environmental instability and weak photocatalytic activity of BPQDs remains a considerable challenge preventing their clinical application. Herein, we have designed new Janus nanoparticles (J-MOPs) based on BPQDs and tetrahydroxyanthraquinone (THQ)-Cu metal-organic particles (MOPs) to simultaneously improve the environmental stability and photocatalytic activity for the PDT treatment of cancers. The J-MOPs were simply assembled from BPQDs and THQ via Cu-mediated P-Cu-THQ host-metal-guest coordination effects. The encapsulation of BPQDs inside J-MOPs and P-Cu bonds effectively isolated BPQDs from water-air and occupied the P lone-pair electrons, respectively, to improve the stability of BPQDs. Furthermore, the dramatic electron-hole separation and migration abilities of J-MOPs increased the reactivity toward O-2, which enhanced singlet oxygen (O-1(2)) generation against cancers compared with BPQDs alone when exposed to 670 nm laser irradiation. Intriguingly, tumor acid-triggered J-MOPs degradation resulted in the release of Cu2+ ions that further served as a Fenton-like agent to generate OH from H2O2, which enhanced the antitumor effects of the J-MOPs. Therefore, we have highlighted the potential of J-MOPs as a photocatalyst for photodynamic cancer therapy.

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最新[2023]版：

大类 | 2 区材料科学

小类 | 3 区化学：综合 3 区材料科学：综合

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无

最新[2023]版：

Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

影响因子： 6 最新[2023版] 6 最新五年平均 0 出版当年[2017版] 0 出版当年五年平均 0 出版前一年[2016版]

第一作者：

第一作者机构： [a]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China. [b]Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China [c]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, P. R. China

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通讯作者：

通讯机构： [a]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China. [b]Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China [c]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, P. R. China [d]Liver Disease Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, P. R. China. [e]Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, P. R. China

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