机构：[a]Department of Anesthesiology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China[b]Department of Anesthesiology, Beijing Anzhen Hospital China Capital Medical University, Beijing, China临床科室麻醉中心首都医科大学附属安贞医院
Objective: This study aimed to analyze the perinatal changes of plasma estradiol (E-2) and angiotensin II (Ang II) in pregnant women with pulmonary arterial hypertension before and after cesarean section. Methods: Depending on pulmonary arterial pressure, the subjects were divided into two groups, moderate group, and severe group. Plasma concentrations of E-2 and Ang II were determined at different time points using electrochemiluminescence immunoassay and ELISA, respectively. The correlation between E2 and Ang II concentrations was analyzed. Results: Intragroup comparison indicated that E2 levels at different time points after surgery decreased in the two groups than before, with a greater reduction in the severe group. Besides, both groups showed a reduction in Ang II concentrations after surgery. As indicated by intragroup comparison, there was a significant difference at each time point in the two groups. The reduction in Ang II concentrations was more conspicuous at 48 h and 72 h after surgery (cesarean section) than before for the two groups. Moreover, E-2 concentrations were correlated positively with AngII concentrations. Conclusion: Plasma concentrations of E-2 and Ang II decreased after delivery. The plasma concentrations of E-2 and Ang II were correlated with each other.
基金：
Application and Popularization of Clinical Research Findings of Beijing [Z151100004015022]
第一作者机构：[a]Department of Anesthesiology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[b]Department of Anesthesiology, Beijing Anzhen Hospital China Capital Medical University, Beijing, China[*1]Department of Anesthesiology, Beijing Anzhen Hospital of China Capital Medical University, NO.2 of Anzhen Street, Chaoyang District, Beijing 100029, China
推荐引用方式(GB/T 7714)：
Yanshuang Wang,Hao Che,Kai Kang,et al.Perinatal changes in estradiol and Ang II concentrations in pregnant women with pulmonary arterial hypertension and their correlation[J].HYPERTENSION IN PREGNANCY.2019,38(3):163-170.doi:10.1080/10641955.2019.1625365.
APA：
Yanshuang Wang,Hao Che,Kai Kang,Guosheng Zhao,Xiaoguang Li...&Liyun Zhao.(2019).Perinatal changes in estradiol and Ang II concentrations in pregnant women with pulmonary arterial hypertension and their correlation.HYPERTENSION IN PREGNANCY,38,(3)
MLA：
Yanshuang Wang,et al."Perinatal changes in estradiol and Ang II concentrations in pregnant women with pulmonary arterial hypertension and their correlation".HYPERTENSION IN PREGNANCY 38..3(2019):163-170
