机构:[1]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, China临床科室心脏内科中心首都医科大学附属安贞医院[2]International School of Capital Medical University, Beijing, China
Background: Coronary artery disease (CAD) in adults <= 35 years of age is rare, but the incidence is on the rise and the risk factors for this age group are largely uncertain. Previous studies have shown that hyperurkemia (HUA) is an independent risk factor for CAD in the general population, whereas the role in adults <= 35 years of age with acute coronary syndrome (ACS) is unclear. Methods: Patients, 18-35 years of age, diagnosed with ACS for the first time at the documented institution between January 2005 and December 2015, were enrolled in the current study. The severity of CAD was assessed by the Gensini score. Patients were divided into two groups according to the definition of HUA. The relationship between HUA and CAD severity was assessed based on multi-variate analysis. Results: Seven hundred seventy-one participants fulfilling the criteria were included in this study (mean age, 31.6 years; 94.4% male). HUA, which was defined as a serum uric acid level >= 7.0 mg/dL (420 mu mol/L) in males and >= 6.0 mg/dL (357 mu mol/L) in females, accounted for 37% of the participants. Multivariate analysis identified that HUA is an independent risk factor of CAD severity, as assessed by the Gensini score, in very young adults with ACS (OR 8.28; 95% CI 1.96-14.59; p = 0.01), and the effect of HUA on CAD severity was second only to diabetes mellitus. Conclusions: Hyperuricemia was shown to be an independent risk factor for CAD severity in young adults with ACS (18-35 years of age).
基金:
Beijing Municipal Administration of Hospitals Clinical Medicine Development of special funding support [ZYLX201303, (sic)5000]; National Key Clinical Specialty Construction Project (2013-2014) [(sic)5000]; Beijing Municipal Administration of Hospitals ascent plan [(sic)5000, DFL20150601]
第一作者机构:[1]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, China
共同第一作者:
通讯作者:
通讯机构:[1]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, China[*1]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Anzhen Ave #2, Chaoyang District, Beijing 100029, China
推荐引用方式(GB/T 7714):
Sai Lv,Wei Liu,Yujie Zhou,et al.Hyperuricemia and severity of coronary artery disease: An observational study in adults 35 years of age and younger with acute coronary syndrome[J].CARDIOLOGY JOURNAL.2019,26(3):275-282.doi:10.5603/CJ.a2018.0022.
APA:
Sai Lv,Wei Liu,Yujie Zhou,Yuyang Liu,Dongmei Shi...&K.S. Shakeenah Ravuru.(2019).Hyperuricemia and severity of coronary artery disease: An observational study in adults 35 years of age and younger with acute coronary syndrome.CARDIOLOGY JOURNAL,26,(3)
MLA:
Sai Lv,et al."Hyperuricemia and severity of coronary artery disease: An observational study in adults 35 years of age and younger with acute coronary syndrome".CARDIOLOGY JOURNAL 26..3(2019):275-282