机构：[1]State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Carbon Fiber and Functional Polymers (Beijing University of Chemical Technology), Ministry of Education, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.[2]Key Laboratory of Remodeling-Related Cardiovascular Diseases (Ministry of Education), and Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, China.首都医科大学附属安贞医院[3]Department of Nuclear Medicine, The First Hospital of Shanxi Medical University, Molecular Imaging Precision Medical Collaborative Innovation Center, Shanxi Medical University, Shanxi 030001, China.[4]Department of Chemical Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
Thoracic aortic dissection (TAD) is an aggressive vascular disease that requires early diagnosis and effective treatment. However, due to the particular vascular structure and narrowness of lesion location, there are no effective drug delivery systems for the therapy of TAD. Here, we report a multifunctional delivery nanosystem (TP-Gd/miRNA-ColIV) composed of gadolinium-chelated tannic acid (TA), low-toxic cationic PGEA (ethanolamine-aminated poly(glycidyl methacrylate)) and type IV collagen targeted peptide (ColIV) for targeted nucleic acid therapy, early diagnosis and noninvasive monitoring of TAD. Such targeted therapy with miR-145 exhibits impressive performances in stabilizing the vascular structures and preventing the deterioration of TAD. After the treatment with TP-Gd/miR145-ColIV, nearly no dissection occurs in the thoracic aortic arches of the mice with TAD model. Moreover, TP-Gd/miRNA-ColIV also demonstrates good magnetic resonance imaging (MRI) ability and can be used to noninvasively monitor the development conditions of TAD.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [51733001, 51829301, 91339000, 91539121]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [XK1802-2]
第一作者机构：[1]State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Carbon Fiber and Functional Polymers (Beijing University of Chemical Technology), Ministry of Education, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Carbon Fiber and Functional Polymers (Beijing University of Chemical Technology), Ministry of Education, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.[2]Key Laboratory of Remodeling-Related Cardiovascular Diseases (Ministry of Education), and Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, China.
推荐引用方式(GB/T 7714)：
Xu Chen,Zhang Yanzhenzi,Xu Ke,et al.Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection[J].NATURE COMMUNICATIONS.2019,10(1):-.doi:10.1038/s41467-019-11068-1.
APA：
Xu, Chen,Zhang, Yanzhenzi,Xu, Ke,Nie, Jing-Jun,Yu, Bingran...&Xu, Fu-Jian.(2019).Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection.NATURE COMMUNICATIONS,10,(1)
MLA：
Xu, Chen,et al."Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection".NATURE COMMUNICATIONS 10..1(2019):-
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