Background: Obstructive sleep apnea (OSA) is associated with several cardiovascular comorbidities including hypertension, arteriosclerosis, and heart failure. Uvulopalatopharyngoplasty (UPPP) is a frequently performed surgical treatment for OSA. Aims/Objectives: To analyze if UPPP can improve cardiac parameters associated with atherosclerosis and reduce the cardiac burden in OSA patients. Material and methods: A prospective cohort study was performed at a single tertiary care center where OSA patients undergoing UPPP were evaluated. Preoperative and 6-month postoperative cardiac parameters namely carotid artery intima-media thickness (CIMT), arterial stiffness parameters, echocardiography, and polysomnography (PSG) results were compared. Results: Fifty three patients were included in the study. The success and response rate of UPPP was 60.4%. Following the surgery, significant reduction in arterial stiffness index (beta) (12.4 +/- 4.1 vs. 11.2 +/- 4.0, p = .01), and elasticity modulus (Ep) (172.8 +/- 68.3 vs. 156.6 +/- 55.3, p = .05) was noticed. Additionally, echocardiographic parameters namely velocity across aortic valve (121.9 +/- 22.9 vs. 109.4 +/- 17.7, p = .01) and velocity across pulmonary valve (107.4 +/- 16.4 vs. 94.2 +/- 16.9, p < .01) significantly decreased following UPPP.