The expression of survivin in irreversible pulmonary arterial hypertension rats and its value in evaluating the reversibility of pulmonary arterial hypertension secondary to congenital heart disease
机构：[1]Pediatric Cardiac Center, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China临床科室小儿心脏中心首都医科大学附属安贞医院[2]Department of Molecular Physiology and Biophysics, Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa City, IA, USA
The reversibility of pulmonary arterial hypertension (PAH) determines the operability of congenital heart disease (CHD) complicating with PAH, but it lacks a method for evaluating the reversibility. The current study aims to investigate the serum survivin level in irreversible PAH rats and to explore its potential as a biomarker for evaluating the reversibility of PAH in CHD patients. Irreversible PAH rats were characterized by prominent obstructive lesions resulting from the intimal formation, which was associated with decreased apoptosis and increased survivin expression, while reversible PAH rats were featured by medial hypertrophy resulting in mild occlusion, with increased apoptosis and unchanged survivin expression. In addition, the serum survivin was significantly increased in irreversible PAH rats when compared to both reversible PAH and control rats, and a positive correlation of serum survivin with survivin expression in the lung was confirmed. Third, the preoperative serum survivin was significantly higher in patients with irreversible CHD-PAH than in these with reversible CHD-PAH, and significant correlations between the serum survivin and BNP, preoperative pulmonary vascular resistance index, and postoperative mean pulmonary arterial pressure were also identified. In conclusion, the increased survivin level is a feature of irreversible PAH and the serum survivin represents a candidate biomarker reflecting the operability of CHD-PAH patients.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81600383]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7164252]; Beijing Municipal Administration of Hospitals [QML20170601]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|4 区心脏和心血管系统4 区呼吸系统
最新[2023]版：
大类|4 区医学
小类|4 区心脏和心血管系统4 区呼吸系统
JCR分区：
出版当年[2017]版：
Q2CARDIAC & CARDIOVASCULAR SYSTEMSQ3RESPIRATORY SYSTEM
最新[2023]版：
Q2CARDIAC & CARDIOVASCULAR SYSTEMSQ3RESPIRATORY SYSTEM
第一作者机构：[1]Pediatric Cardiac Center, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China
通讯作者：
通讯机构：[1]Pediatric Cardiac Center, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China[*1]Pediatric Cardiac Center, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China.
推荐引用方式(GB/T 7714)：
Li Gang,Zhang Han,Zhao Lei,et al.The expression of survivin in irreversible pulmonary arterial hypertension rats and its value in evaluating the reversibility of pulmonary arterial hypertension secondary to congenital heart disease[J].PULMONARY CIRCULATION.2019,9(3):-.doi:10.1177/2045894019859480.
APA：
Li, Gang,Zhang, Han,Zhao, Lei,Zhang, Yaozhong,Yan, Daole...&Fan, Xiangming.(2019).The expression of survivin in irreversible pulmonary arterial hypertension rats and its value in evaluating the reversibility of pulmonary arterial hypertension secondary to congenital heart disease.PULMONARY CIRCULATION,9,(3)
MLA：
Li, Gang,et al."The expression of survivin in irreversible pulmonary arterial hypertension rats and its value in evaluating the reversibility of pulmonary arterial hypertension secondary to congenital heart disease".PULMONARY CIRCULATION 9..3(2019):-
