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Disseminated sporotrichosis following iatrogenic immunosuppression for suspected pyoderma gangrenosum.

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收录情况： ◇ SCIE

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机构： [a]Department of Pathology, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA [b]Microbiology Laboratory, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA [c]Division of Infectious Diseases, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA [d]Department of Dermatology, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA [e]Department of Pathology and Laboratory Medicine, Veterans Affairs Portland Health Care System, Oregon Health and Science University, Portland, OR, USA [f]Department of Dermatology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

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Sporotrichosis is an infection caused by the dimorphic fungus Sporothrix schenckii and related species that often arises from traumatic inoculation of inhabited soil and organic debris into skin. The infection is usually limited to the skin in immunocompetent patients, usually as lymphocutaneous sporotrichosis. Accurate diagnosis rests on clinical data and culture, and might be facilitated by biopsy identification of suppurative and granulomatous inflammation with fungal elements. In this Grand Round, we present a dramatic case of cutaneous sporotrichosis initially presented with an atypical large ulcer without associated lymphocutaneous spread, clinically mimicking pyoderma gangrenosum, and subsequently progressed to disseminated sporotrichosis in the setting of iatrogenic immunosuppression. We further review the clinical features, risk factors, and treatment of these disseminated sporotrichosis cases, and discuss the need for improved awareness of this fungus' potential link to cause disseminated and invasive fungal infections. Copyright © 2019 Elsevier Ltd. All rights reserved.

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出版当年[2018]版：

大类 | 1 区

医学

小类 | 1 区传染病学

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区传染病学

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出版当年[2017]版：

Q1 INFECTIOUS DISEASES

最新[2023]版：

Q1 INFECTIOUS DISEASES

影响因子： 36.4 最新[2023版] 32.4 最新五年平均 25.148 出版当年[2017版] 22.668 出版当年五年平均 19.864 出版前一年[2016版] 27.516 出版后一年[2018版]

第一作者：

第一作者机构： [a]Department of Pathology, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA

通讯作者：

通讯机构： [a]Department of Pathology, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA [b]Microbiology Laboratory, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA [*1]Department of Pathology, Microbiology Laboratory, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, MD 21287, USA

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