机构：[1]Laboratory of Cardiac Electrophysiology, “Evangelismos” General Hospital of Athens, Greece[2]Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, People’s Republic of China[3]Department of Cardiology, University Hospital of Ioannina, Greece[4]Electrophysiology Section, St. Josefs-Hospital, Wiesbaden, Germany[5]Second Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Greece[6]Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan[7]Lankenau Institute for Medical Research, Wynnewood, PA, USA[8]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China临床科室心脏内科中心首都医科大学附属安贞医院
The early repolarization (ER) pattern has been linked to an increased risk for arrhythmic death in various clinical settings. There are limited and conflicting data regarding the prognostic significance of ER pattern in Brugada syndrome (BS). The aim of this meta-analysis was to provide a detailed analysis of the currently available studies regarding the arrhythmic risk in patients with BS and ER pattern. Current databases were searched until May 2015. A random-effect meta-analysis of the effect of ER pattern on the incidence of arrhythmic events in patients with BS was performed. Five studies were included comprising a total of 1375 patients with BS. An ER pattern was reported in 177 patients (12.8%). During follow-up (44.9-93 months), 143 patients (10.4%) suffered an arrhythmic event. Overall, BS patients with ER pattern displayed an increased risk of arrhythmic events compared to patients without ER (OR 3.29, 95% CI: 2.06 to 5.26, P < 0.00001; Heterogeneity: P = 0.11, I-2 = 48%). Three studies provided data regarding ER pattern location. Inferior, lateral, or inferolateral ER pattern location was observed in 20.3%, 32.2%, and 48%, respectively. An inferolateral ER location conferred the higher arrhythmic risk (OR 4.87, 95% CI: 2.64 to 9.01, P < 0.00001; Heterogeneity: P = 0.85, I-2 = 0%). This meta-analysis suggests that the ER pattern is associated with a high risk of arrhythmic events in patients with BS. In particular, BS patients with inferolateral ER (global ER pattern) displayed the highest arrhythmic risk.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81370289]; Sharpe-Strumia Research Foundation
第一作者机构：[1]Laboratory of Cardiac Electrophysiology, “Evangelismos” General Hospital of Athens, Greece
通讯作者：
通讯机构：[1]Laboratory of Cardiac Electrophysiology, “Evangelismos” General Hospital of Athens, Greece
推荐引用方式(GB/T 7714)：
Georgopoulos Stamatis,Letsas Konstantinos P.,Liu Tong,et al.A meta-analysis on the prognostic significance of inferolateral early repolarization pattern in Brugada syndrome[J].EUROPACE.2018,20(1):134-139.doi:10.1093/europace/euw394.
APA：
Georgopoulos, Stamatis,Letsas, Konstantinos P.,Liu, Tong,Kalafateli, Maria,Korantzopoulos, Panagiotis...&Ehrlich, Joachim R..(2018).A meta-analysis on the prognostic significance of inferolateral early repolarization pattern in Brugada syndrome.EUROPACE,20,(1)
MLA：
Georgopoulos, Stamatis,et al."A meta-analysis on the prognostic significance of inferolateral early repolarization pattern in Brugada syndrome".EUROPACE 20..1(2018):134-139
医学