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Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta-analysis

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机构: [1]Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, P.R. China [2]Department of Medicine and Therapeutics, ChineseUniversity of Hong Kong, Hong Kong, SAR, P.R. China [3]Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, SAR, P.R. China [4]School of Health Sciences, University ofManchester, Manchester,United Kingdom [5]Department of Epidemiology and Preventive Medicine,MonashUniversity, Clayton, VIC, Australia [6]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, P.R. China [7]Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuhan, Hubei, P.R. China [8]Department of Cardiology, First Affiliated Hospital ofDalianMedical University, Dalian, P.R. China [9]Lankenau Institute forMedical Research and Lankenau Medical Center, Wynnewood, PA, USA [10]Beijing Anzhen Hospital, CapitalMedical University, Beijing, China
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关键词: atrial fibrillation meta-analysis prolonged QTc interval risk

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BackgroundCorrected QT interval (QTc) on the electrocardiogram is a marker of ventricular repolarization. Recent studies have examined its value in predicting the occurrence of atrial fibrillation (AF). Methods and resultsWe conducted a meta-analysis to determine whether alterations in QTc interval are associated with an increased risk of incident AF. The PUBMED and EMBASE databases were searched for all studies that evaluated the incident AF associated with prolonged QTc interval published before December 2016. Sensitivity and subgroup analysis were subsequently performed. A total of six studies including eight data sets for prolonged QTc interval were eligible. Subjects with prolonged QTc interval as a categorical variable had a significantly higher risk of AF during follow-up (hazard ratio [HR]: 1.16; 95% confidence interval [CI], 1.09-1.24, I-2=90%) based on Bazett formula. In continuous variable analysis, we found a statistically significant risk for AF (HR, 1.17; 95% CI, 1.09-1.25; I-2=0) every 10-ms prolongation in QTc. AF type, QTc cut-off value, geographical location, follow-up duration, and study population may be the possible reasons for the significant heterogeneity among the studies. ConclusionsProlonged QTc interval is associated with an increased risk of AF. And the potential mechanisms underlying this cause-and-effect relationship need further investigation.

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出版当年[2017]版:
大类 | 4 区 医学
小类 | 4 区 心脏和心血管系统 4 区 工程:生物医学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 心脏和心血管系统 4 区 工程:生物医学
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出版当年[2016]版:
Q3 ENGINEERING, BIOMEDICAL Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
最新[2023]版:
Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Q3 ENGINEERING, BIOMEDICAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

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第一作者机构: [1]Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, P.R. China
通讯作者:
通讯机构: [1]Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, P.R. China [*1]TianjinKey Laboratory of Ionic-Molecular Function ofCardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, No. 23,Pingjiang Road,HexiDistrict, Tianjin 300211,People's Republic of China.
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