机构:[1]Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, P.R. China[2]Department of Medicine and Therapeutics, ChineseUniversity of Hong Kong, Hong Kong, SAR, P.R. China[3]Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, SAR, P.R. China[4]School of Health Sciences, University ofManchester, Manchester,United Kingdom[5]Department of Epidemiology and Preventive Medicine,MonashUniversity, Clayton, VIC, Australia[6]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, P.R. China[7]Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuhan, Hubei, P.R. China[8]Department of Cardiology, First Affiliated Hospital ofDalianMedical University, Dalian, P.R. China内科科室心内科大连医科大学附属第一医院[9]Lankenau Institute forMedical Research and Lankenau Medical Center, Wynnewood, PA, USA[10]Beijing Anzhen Hospital, CapitalMedical University, Beijing, China首都医科大学附属安贞医院
BackgroundCorrected QT interval (QTc) on the electrocardiogram is a marker of ventricular repolarization. Recent studies have examined its value in predicting the occurrence of atrial fibrillation (AF). Methods and resultsWe conducted a meta-analysis to determine whether alterations in QTc interval are associated with an increased risk of incident AF. The PUBMED and EMBASE databases were searched for all studies that evaluated the incident AF associated with prolonged QTc interval published before December 2016. Sensitivity and subgroup analysis were subsequently performed. A total of six studies including eight data sets for prolonged QTc interval were eligible. Subjects with prolonged QTc interval as a categorical variable had a significantly higher risk of AF during follow-up (hazard ratio [HR]: 1.16; 95% confidence interval [CI], 1.09-1.24, I-2=90%) based on Bazett formula. In continuous variable analysis, we found a statistically significant risk for AF (HR, 1.17; 95% CI, 1.09-1.25; I-2=0) every 10-ms prolongation in QTc. AF type, QTc cut-off value, geographical location, follow-up duration, and study population may be the possible reasons for the significant heterogeneity among the studies. ConclusionsProlonged QTc interval is associated with an increased risk of AF. And the potential mechanisms underlying this cause-and-effect relationship need further investigation.
基金:
This work was supported by grants (81570298, 30900618, 81270245
to T.L.) from the National Natural Science Foundation of China, Tianjin
Natural Science Foundation (16JCZDJC34900 to T.L.).
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外文
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PubmedID:
中科院(CAS)分区:
出版当年[2017]版:
大类|4 区医学
小类|4 区心脏和心血管系统4 区工程:生物医学
最新[2023]版:
大类|4 区医学
小类|4 区心脏和心血管系统4 区工程:生物医学
JCR分区:
出版当年[2016]版:
Q3ENGINEERING, BIOMEDICALQ4CARDIAC & CARDIOVASCULAR SYSTEMS
第一作者机构:[1]Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, P.R. China
通讯作者:
通讯机构:[1]Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, P.R. China[*1]TianjinKey Laboratory of Ionic-Molecular Function ofCardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, No. 23,Pingjiang Road,HexiDistrict, Tianjin 300211,People's Republic of China.
推荐引用方式(GB/T 7714):
Zhang Nixiao,Gong Mengqi,Tse Gary,et al.Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta-analysis[J].PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY.2018,41(3):321-327.doi:10.1111/pace.13292.
APA:
Zhang, Nixiao,Gong, Mengqi,Tse, Gary,Zhang, Zhiwei,Meng, Lei...&Liu, Tong.(2018).Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta-analysis.PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY,41,(3)
MLA:
Zhang, Nixiao,et al."Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta-analysis".PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY 41..3(2018):321-327