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Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration

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机构: [1]Goethe Univ, Dept Neurol, Frankfurt, Germany; [2]Univ Forvie Site, MRC, Biostat Unit, Inst Publ Hlth, Cambridge, England; [3]Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy; [4]Bassini Hosp, SISA Ctr Study Atherosclerosis, Cinisello Balsamo, Italy; [5]Univ Paris 05, Sorbonne Paris Cite, UMR, Paris Cardiovasc Res Ctr PARCC, Paris, France; [6]Univ Med Mainz, IMBEI, Mainz, Germany; [7]Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan; [8]Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland; [9]Gothenburg Univ, Sahlgrenska Acad, Dept Mol & Clin Med, Wallenberg Lab Cardiovasc Res,Inst Medicin, Gothenburg, Sweden; [10]Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio Campus, Kuopio, Finland; [11]IRCCS, Ctr Cardiol Monzino, Milan, Italy; [12]Greifswald Univ Clin, Dept Neurol, Greifswald, Germany; [13]Tulane Univ, Sch Publ Hlth & Trop Med, Ctr Cardiovasc Hlth, Dept Epidemiol,Biochem, New Orleans, LA USA; [14]Uppsala Univ, Dept Med, Uppsala, Sweden; [15]Osaka Univ, Grad Sch Med, Dept Neurol, Osaka, Japan; [16]Maastricht Univ, Med Ctr, Dept Internal Med, Maastricht, Netherlands; [17]Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht CARIM, Maastricht, Netherlands; [18]Med Univ Innsbruck, Dept Neurol, Innsbruck, Austria; [19]Univ Cambridge, Sch Clin Med, Dept Publ Hlth & Primary Care, Cambridge, England; [20]Tufts Univ, Sch Med, Tufts Med Ctr, Boston, MA 02111 USA; [21]Benedictus Hosp Tutzing & Feldafing, Dept Neurol, Feldafing, Germany; [22]Tech Univ Munich, Dept Neurol, Munich, Germany; [23]Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA; [24]Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands; [25]Erasmus Univ, Med Ctr, Dept Neurol, Rotterdam, Netherlands; [26]Erasmus Univ, Med Ctr, Dept Radiol, Rotterdam, Netherlands; [27]Uit, Dept Clin Med, Tromso, Norway; [28]Univ Hosp Northern Norway, Dept Neurol, Tromso, Norway; [29]Univ Basel Hosp, Dept Angiol, Basel, Switzerland; [30]Osped Niguarda Ca Granda, Ctr Dyslipidemias, Milan, Italy; [31]Parcelsus Med Univ, Salzburg, Austria; [32]Gemeinnutzige Salzburger Landeskliniken Betriebsg, Doppler Klin, Dept Geriatr Med, Salzburg, Austria; [33]Univ Navarra Clin, Dept Internal Med, Navarra, Spain; [34]Lund Univ, Dept Clin Sci, Malmo, Sweden; [35]Univ Autonoma Madrid, Hosp Univ La Princesa, Dept Radiol, Madrid, Spain; [36]Univ Naples Federico II, Sch Med, Naples, Italy; [37]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Dept Epidemiol, Beijing, Peoples R China; [38]Western Univ, Roberts Res Inst, London, ON, Canada; [39]Bassini Hosp, Ctr Sisa Studio Aterosclerosi, Cinisello Balsamo, Italy; [40]Hop Broca, AP HP, Paris, France; [41]Johannes Gutenberg Univ Mainz, Dept Med 2, Mainz, Germany; [42]Univ Hosp Hamburg Eppendorf, Dept Cardiol, Hamburg, Germany; [43]Univ Gothenburg, Wallenberg Lab Cardiovasc Res, Gothenburg, Sweden; [44]German Ctr Cardiovasc Res DZHK, Partner Site Greifswald, Greifswald, Germany; [45]Inst Community Med, SHIP Clin Epidemiol Res, Greifswald, Germany; [46]Vrije Univ Amsterdam, Dept Gen Practice, Medial Ctr, Amsterdam, Netherlands; [47]Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands; [48]Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA; [49]Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands; [50]Univ Autonoma Madrid, Hosp Univ La Princesa, Dept Internal Med, Madrid, Spain; [51]Western Univ, Stroke Prevent & Atherosclerosis Res Ctr, Roberts Res Inst, London, ON, Canada; [52]Mahidol Univ, Dept Internal Med, Fac Med, Siriraj Hosp, Bangkok, Thailand; [53]IRCSS Multimed, Milan, Italy; [54]Univ Milan, Dept Pharmacol & Biomol Sci, Milan, Italy; [55]Univ Paris Sud Xi, Le Kremlin Bicetre, France; [56]Johannes Gutenberg Univ Mainz, Dept Med 2, Mainz, Germany; [57]Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan; [58]Gothenburg Univ, Wallenberg Lab Cardiovasc Res, Sahlgrenska Acad, Gotheborg, Sweden; [59]Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany; [60]Tulane Univ, Sch Med, Dept Med, Pediat,Biochem,Epidemiol, 1430 Tulane Ave, New Orleans, LA 70112 USA; [61]Sch Publ Hlth & Trop Med, New Orleans, LA USA; [62]Tokyo Womens Med Univ, Dept Neurol, Tokyo, Japan; [63]Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Dept Epidemiol & Biostat, Amsterdam, Netherlands; [64]Klinikum Herford, Dept Neuol, Herford, Germany; [65]Tech Univ Munich, Dept Psychiat & Psychotherapy, Munich, Germany; [66]Lund Univ, Dept Clin Sci Malmo, Malmo, Sweden; [67]Inst Salud Carlos III, Escuela Natl Sanidad, Madrid, Spain; [68]Erasmus MC, Dept Epidemiol & Biostat, Rotterdam, Netherlands; [69]Imagelabonline & Cardiovasc, Eindhoven, Netherlands; [70]Imagelabonline & Cardiovasc, Lunteren, Netherlands; [71]Acad Med Ctr, Dept Clin Epidemiol Biostat & Bioinformat, Amsterdam, Netherlands; [72]Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands; [73]Univ Washington, Dept Biostat, Seattle, WA 98195 USA
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Aims Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C. Conclusions We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.

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出版当年[2017]版:
大类 | 3 区 生物
小类 | 3 区 综合性期刊
最新[2023]版:
大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
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出版当年[2016]版:
Q1 MULTIDISCIPLINARY SCIENCES
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Q1 MULTIDISCIPLINARY SCIENCES

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第一作者机构: [1]Goethe Univ, Dept Neurol, Frankfurt, Germany;
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通讯机构: [1]Goethe Univ, Dept Neurol, Frankfurt, Germany;
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