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Atherosclerosis T1-weighted characterization (CATCH): evaluation of the accuracy for identifying intraplaque hemorrhage with histological validation in carotid and coronary artery specimens

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收录情况： ◇ SCIE

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机构： [1]Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. [2]Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. [3]Department of Cardiac Surgery, Anzhen Hospital, Capital Medical University, Beijing, China. [4]Departments of Medicine and Bioengineering, University of California, Los Angeles, CA, USA. [5]MR R&D, Siemens Healthineers, Los Angeles, CA, USA. [6]MR Collaborations NE Asia, Siemens Healthcare, Beijing, China. [7]Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

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关键词： Coronary high intensity plaques (CHIPs) T1w imaging Intraplaque hemorrhage CATCH

摘要：

Background: Coronary high intensity plaques (CHIPs) detected using cardiovascular magnetic resonance (CMR) coronary atherosclerosis T1-weighted characterization with integrated anatomical reference (CATCH) have been shown to be positively associated with high-risk morphology observed on intracoronary optical coherence tomography (OCT). This study sought to validate whether CHIPs detected on CATCH indicate the presence of intraplaque hemorrhage (IPH) through ex vivo imaging of carotid and coronary plaque specimens, with histopathology as the standard reference. Methods: Ten patients scheduled to undergo carotid endarterectomy underwent CMR with the conventional T1-weighted (T1w) sequence. Eleven carotid atherosclerotic plaques removed at carotid endarterectomy and six coronary artery endarterectomy specimens removed from patients undergoing coronary artery bypass grafting (CABG) were scanned ex vivo using both the conventional T1w sequence and CATCH. Both in vivo and ex vivo images were examined for the presence of IPH. The sensitivity, specificity, and Cohen Kappa (k) value of each scan were calculated using matched histological sections as the reference. k value between each scan in the discrimination of IPH was also computed. Results: A total of 236 in vivo locations, 328 ex vivo and matching histology locations were included for the analysis. Sensitivity, specificity, and k value were 76.7%, 95.3%, and 0.75 for in vivo T1w imaging, 77.2%, 97.4%, and 0.78 for ex vivo T1w imaging, and 95.0%, 92.1%, and 0.84 for ex vivo CATCH, respectively. Moderate agreement was reached between in vivo T1w imaging, ex vivo T1w imaging, and ex vivo CATCH for the detection of IPH: between in vivo T1w imaging and ex vivo CATCH (k = 0.68), between ex vivo T1w imaging and ex vivo CATCH (k = 0.74), between in vivo T1w imaging and ex vivo T1w imaging (k = 0.83). None of the coronary artery plaque locations showed IPH. Conclusion: This study demonstrated that carotid CHIPs detected by CATCH can be used to assess for IPH, a high-risk plaque feature.

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出版当年[2017]版：

大类 | 2 区医学

小类 | 2 区心脏和心血管系统 2 区核医学

最新[2023]版：

大类 | 1 区医学

小类 | 2 区心脏和心血管系统 2 区核医学

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出版当年[2016]版：

Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

最新[2023]版：

Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 4.2 最新[2023版] 5.5 最新五年平均 5.601 出版当年[2016版] 6.037 出版当年五年平均 5.752 出版前一年[2015版] 5.457 出版后一年[2017版]

第一作者：

第一作者机构： [1]Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

通讯作者：

通讯机构： [1]Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

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Atherosclerosis T1-weighted characterization (CATCH): evaluation of the accuracy for identifying intraplaque hemorrhage with histological validation in carotid and coronary artery specimens

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