机构：[1]Department of Pathophysiology, Key Laboratory of Cardiovascular Pathophysiology, Harbin Medical University, Harbin, China.[2]Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China首都医科大学附属安贞医院
Nonalcoholic fatty liver disease (NAFLD) is a worldwide chronic liver disease. Few studies have investigated the association between NAFLD and Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), a unique enzyme correlated with oxidative stress. The aim of this study was to assess the relationship between Lp-PLA2 and NAFLD in a Chinese community-based cohort. A total of 1587 adults aged >= 40 years were enrolled in the current study. Participants underwent a standardized evaluation. The serum Lp-PLA2 concentration was measured by ELISA and NAFLD was diagnosed by ultrasonography. Multivariable logistic regression was used to assess the association between Lp-PLA2 and NAFLD. Increased Lp-PLA2 levels were significantly associated with decreased NAFLD prevalence after adjusting for other potential confounders. The adjusted ORs of NAFLD in Q2, Q3 and Q4 compared with Q1 were 0.88 (0.64-1.21), 0.71 (0.51-0.98) and 0.67 (0.48-0.95), respectively (P < 0.05). Furthermore, the adjusted ORs of moderate and heavy NAFLD in Q2, Q3 and Q4 compared to Q1 were 0.64 (0.41-1.01), 0.48 (0.29-0.80) and 0.47 (0.28-0.79), respectively (P < 0.01). In conclusions, increased Lp-PLA2 levels were independently associated with decreased NAFLD prevalence.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81571833, 81271734, 81000688, 81670294, 81202279, 81473057]; Heilongjiang Provincial Science Foundation [H2015006]; Foundation of Science and Technology Innovation Talent of Harbin Science and Technology Bureau [2015RAQXJ100]; Wu Liande Youth Science Foundation of Harbin Medical University [WLD-QN1104]; Postdoctoral Science-Research Developmental Foundation of Heilongjiang Province [LBHQ12049]; Nn10 plan - Harbin Medical University Cancer Hospital
第一作者机构：[1]Department of Pathophysiology, Key Laboratory of Cardiovascular Pathophysiology, Harbin Medical University, Harbin, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pathophysiology, Key Laboratory of Cardiovascular Pathophysiology, Harbin Medical University, Harbin, China.[2]Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Zhongni Liu,Hong Li,Yinghong Zheng,et al.Association of Lipoprotein-Associated Phospholipase A2 with the Prevalence of Nonalcoholic Fatty Liver Disease: A Result from the APAC Study[J].SCIENTIFIC REPORTS.2018,8(1):-.doi:10.1038/s41598-018-28494-8.
APA：
Zhongni Liu,Hong Li,Yinghong Zheng,Ziyu Gao,Lin Cong...&Yong Zhou.(2018).Association of Lipoprotein-Associated Phospholipase A2 with the Prevalence of Nonalcoholic Fatty Liver Disease: A Result from the APAC Study.SCIENTIFIC REPORTS,8,(1)
MLA：
Zhongni Liu,et al."Association of Lipoprotein-Associated Phospholipase A2 with the Prevalence of Nonalcoholic Fatty Liver Disease: A Result from the APAC Study".SCIENTIFIC REPORTS 8..1(2018):-
