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Increased Soluble CD137 Levels and CD4+T-Cell-Associated Expression of CD137 in Acute Atherothrombotic Stroke

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收录情况： ◇ SCIE

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机构： [1]Department of Neurology, Peking University People’s Hospital, Beijing, China [2]Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

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As a proinflammatory cytokine, CD137 (4-1BB, TNFRSF9) is present in membrane-bound and soluble forms. Increased expression of CD137 was recently found in T cells in human atherosclerotic plaques. However, the exact role of CD137 in ischemic stroke is not clear. In this study we analyzed the protein levels of soluble CD137 (sCD137) and the expression of CD137 on CD4+ T cells in the peripheral blood of patients with acute atherothrombotic stroke by using the cytometry beads array (CBA) and flow cytometry. Within 24 hours of onset, the stroke patients showed elevated levels of sCD137 (2.7 pg/ml) and CD137 expression on CD4+ T cells (4.9 +/- 3.2%) compared with normal controls (1.1 pg/ml, P < 0.01; 1.3 +/- 1.0%, P < 0.01). Alterations in CD137 expression may enhance ischemia-induced inflammatory responses via bidirectional signaling and, consequently, aggravate brain injury in early stages of this disorder.

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出版当年[2017]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

最新[2025]版：

大类 | 3 区医学

小类 | 3 区医学：研究与实验

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出版当年[2016]版：

Q4 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q2 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 3.1 最新[2023版] 3.6 最新五年平均 0.86 出版当年[2016版] 1.265 出版当年五年平均 1.052 出版前一年[2015版] 1.954 出版后一年[2017版]

第一作者：

第一作者机构： [1]Department of Neurology, Peking University People’s Hospital, Beijing, China

通讯作者：

通讯机构： [1]Department of Neurology, Peking University People’s Hospital, Beijing, China

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