Role of Gated Myocardial Glucose Metabolic Imaging in Assessing Left Ventricular Systolic Dyssynchrony after Myocardial Infarction and the Influential Factors
机构：[1]Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.[2]Department of Nuclear Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.医技科室核医学科首都医科大学附属安贞医院[3]Department of Anesthesiology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
In this study, we investigated the role of gated myocardial glucose metabolic imaging in assessing left ventricular (LV) systolic dyssynchrony after myocardial infarction (MI) and explored the influencing factors. Bama mini-pigs were divided into normal group and MI group and subjected to gated myocardial metabolic imaging (GMMI) and gated myocardial perfusion imaging (GMPI). The phase bandwidth (BW), standard deviation (SD) and the latest activation site of left ventricle were obtained using program Cedars QGS. The results showed that (1) BW and SD obtained in GMMI and GMPI showed significant correlation in pigs with MI, but not in the normal pigs, (2) BW and SD obtained in GMMI and GMPI had good consistency in both normal pigs and MI pigs, (3) GMMI and GMPI had a 66.7% identity in determining the latest activation site of left ventricle in the normal pigs and 77.8% identity in determining the latest activation site of left ventricle in pigs with MI. Multivariate stepwise regression analysis showed that total perfusion deficit and summed motion score were independent factors affecting BW and SD in GMMI. In conclusion, phase analysis of GMMI images could objectively reflect LV systolic dyssynchrony resulted from interactions of multiple factors.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81471690]; Youth Science Fund Project of National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81701734, 81701737]; Jiangsu Province Science and Technology Program-Project of Standardized Diagnosis and Treatment of Key Diseases [BE2015635]; Key Project of Changzhou Municipal Health Bureau [ZD201409]
第一作者机构：[1]Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
通讯作者：
通讯机构：[1]Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
推荐引用方式(GB/T 7714)：
Xiaoliang Shao,Jianfeng Wang,Yi Tian,et al.Role of Gated Myocardial Glucose Metabolic Imaging in Assessing Left Ventricular Systolic Dyssynchrony after Myocardial Infarction and the Influential Factors[J].SCIENTIFIC REPORTS.2018,8(1):-.doi:10.1038/s41598-018-29636-8.
APA：
Xiaoliang Shao,Jianfeng Wang,Yi Tian,Shengdeng Fan,Feifei Zhang...&Yuetao Wang.(2018).Role of Gated Myocardial Glucose Metabolic Imaging in Assessing Left Ventricular Systolic Dyssynchrony after Myocardial Infarction and the Influential Factors.SCIENTIFIC REPORTS,8,(1)
MLA：
Xiaoliang Shao,et al."Role of Gated Myocardial Glucose Metabolic Imaging in Assessing Left Ventricular Systolic Dyssynchrony after Myocardial Infarction and the Influential Factors".SCIENTIFIC REPORTS 8..1(2018):-
