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Bioabsorbable Drug-Eluting Stent Versus Bare Metal Stent in Iliac Artery Evaluated by Optical Coherence Tomography: An In Vivo Study in Porcine

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机构: [1]Department of Vascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China [2]Division of Vascular and Endovascular Surgery, University of Washington, Puget Sound VA Healthcare System, Seattle, WA, USA
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关键词: bioabsorbable drug-eluting stent bare metal stent optical coherence tomography average neointimal thickness

摘要:
Objective: This study aimed to compare, using optical coherence tomography (OCT), the outcomes of bioabsorbable drug-eluting stent with those of bare metal stent (BMS) following implantation in porcine iliac artery.Methods: After the placement of BMS and bioabsorbable drug-eluting stents, we used OCT and digital subtraction angiography to investigate stent appositions, arterial neointima, evagination, and restenosis at 1 and 3 months. Results: At 1 and 3 months after stent implantation, OCT study was performed to investigate 32 stents and 21 788 struts. Thirty-three malapposed struts were found in the bioabsorbable drug-eluting stent groups and 2 were found in BMS groups. The average neointimal thickness, area, and in-stent stenosis were significantly lower in bioabsorbable drug-eluting stents than in BMS, while the frequency of malapposed struts was higher in the bioresorbable drug-eluting stent groups. Average neointimal thickness was lower in bioabsorbable drug-eluting stents than in BMS at 1 (0.19 +/- 0.09 vs 0.67 +/- 0.75 mm; P < .001) and 3 months (0.21 +/- 0.08 vs 1.52 +/- 0.28 mm; P < .001). Conclusion: Our study suggested that bioabsorbable drug-eluting stent is more effective in decreasing arterial restenosis than BMS in animal models.

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出版当年[2017]版:
大类 | 4 区 医学
小类 | 4 区 外周血管病 4 区 外科
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 外周血管病 4 区 外科
JCR分区:
出版当年[2016]版:
Q3 SURGERY Q4 PERIPHERAL VASCULAR DISEASE
最新[2023]版:
Q4 PERIPHERAL VASCULAR DISEASE Q4 SURGERY

影响因子: 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

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第一作者机构: [1]Department of Vascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
通讯作者:
通讯机构: [1]Department of Vascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China [*1]Department of Vascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
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