机构:[1]Department of Vascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China临床科室血管科首都医科大学附属安贞医院[2]Division of Vascular and Endovascular Surgery, University of Washington, Puget Sound VA Healthcare System, Seattle, WA, USA
Objective: This study aimed to compare, using optical coherence tomography (OCT), the outcomes of bioabsorbable drug-eluting stent with those of bare metal stent (BMS) following implantation in porcine iliac artery.Methods: After the placement of BMS and bioabsorbable drug-eluting stents, we used OCT and digital subtraction angiography to investigate stent appositions, arterial neointima, evagination, and restenosis at 1 and 3 months. Results: At 1 and 3 months after stent implantation, OCT study was performed to investigate 32 stents and 21 788 struts. Thirty-three malapposed struts were found in the bioabsorbable drug-eluting stent groups and 2 were found in BMS groups. The average neointimal thickness, area, and in-stent stenosis were significantly lower in bioabsorbable drug-eluting stents than in BMS, while the frequency of malapposed struts was higher in the bioresorbable drug-eluting stent groups. Average neointimal thickness was lower in bioabsorbable drug-eluting stents than in BMS at 1 (0.19 +/- 0.09 vs 0.67 +/- 0.75 mm; P < .001) and 3 months (0.21 +/- 0.08 vs 1.52 +/- 0.28 mm; P < .001). Conclusion: Our study suggested that bioabsorbable drug-eluting stent is more effective in decreasing arterial restenosis than BMS in animal models.
基金:
Cordis Medical Devices, CO., Ltd; Beijing Advanced Medical Technologies, Ltd. Inc; Gateway Medical Innovation Center
第一作者机构:[1]Department of Vascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
通讯作者:
通讯机构:[1]Department of Vascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China[*1]Department of Vascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
推荐引用方式(GB/T 7714):
Zhao Yaping,Chen Zhong,Zhang Wayne W.,et al.Bioabsorbable Drug-Eluting Stent Versus Bare Metal Stent in Iliac Artery Evaluated by Optical Coherence Tomography: An In Vivo Study in Porcine[J].VASCULAR AND ENDOVASCULAR SURGERY.2018,52(7):512-519.doi:10.1177/1538574418783528.
APA:
Zhao, Yaping,Chen, Zhong,Zhang, Wayne W.,Wang, Sheng,Yang, Yaoguo&Yang, Liao.(2018).Bioabsorbable Drug-Eluting Stent Versus Bare Metal Stent in Iliac Artery Evaluated by Optical Coherence Tomography: An In Vivo Study in Porcine.VASCULAR AND ENDOVASCULAR SURGERY,52,(7)
MLA:
Zhao, Yaping,et al."Bioabsorbable Drug-Eluting Stent Versus Bare Metal Stent in Iliac Artery Evaluated by Optical Coherence Tomography: An In Vivo Study in Porcine".VASCULAR AND ENDOVASCULAR SURGERY 52..7(2018):512-519