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CD90 determined two subpopulations of glioma-associated mesenchymal stem cells with different roles in tumour progression

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收录情况： ◇ SCIE

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机构： [1]Department of Neurosurgery,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. [2]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, No. 2, Anzhen Road, Chaoyang District, Beijing 100029, China. [3]Institute of Infection and Immunology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. [4]Department of Neurosurgery, Faculty of Medicine, Helwan University, Cairo 11435, Egypt. [5]Jiangsu Key Lab of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China

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Human glioma-associated mesenchymal stem cells (gbMSCs) are the stromal cell components that contribute to the tumourigenesis of malignant gliomas. Recent studies have shown that gbMSCs consist of two distinct subpopulations (CD90(+) and CD90-gbMSCs). However, the different roles in glioma progression have not been expounded. In this study, we found that the different roles of gbMSCs in glioma progression were associated with CD90 expression. CD90(high) gbMSCs significantly drove glioma progression mainly by increasing proliferation, migration and adhesion, where as CD90(low) gbMSCs contributed to glioma progression chiefly through the transition to pericytes and stimulation of vascular formation via vascular endothelial cells. Furthermore, discrepancies in long non-coding RNAs and mRNAs expression were verified in these two gbMSC subpopulations, and the potential underlying molecular mechanism was discussed. Our data confirm for the first time that CD90(high) and CD90(low) gbMSCs play different roles in human glioma progression. These results provide new insights into the possible future use of strategies targeting gbMSC subpopulations in glioma patients.

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出版当年[2017]版：

大类 | 2 区生物

小类 | 3 区细胞生物学

最新[2023]版：

大类 | 1 区

生物学

小类 | 2 区细胞生物学

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出版当年[2016]版：

Q1 CELL BIOLOGY

最新[2023]版：

Q1 CELL BIOLOGY

影响因子： 8.1 最新[2023版] 8.6 最新五年平均 5.965 出版当年[2016版] 6.147 出版当年五年平均 5.378 出版前一年[2015版] 5.638 出版后一年[2017版]

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第一作者机构： [1]Department of Neurosurgery,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

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通讯机构： [1]Department of Neurosurgery,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

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