机构:[a]Department of Medical Imaging, Western University, London ON, Canada[b]School of Computer Science and Technology, Anhui University, Hefei, China[c]Department of Medical Imaging, Beijing Anzhen Hospital, Capital Medical University, Beijing, China医技科室医学影像科首都医科大学附属安贞医院[d]School of Biomedical Engineering, Sun Yat-Sen University, Shenzhen, China[e]University 2020 Foundation, MA,USA[f]Department of Optical Engineering, Zhejiang University, Hangzhou, China
Changes in mechanical properties of myocardium caused by a infarction can lead to kinematic abnormalities. This phenomenon has inspired us to develop this work for delineation of myocardial infarction area directly from non-contrast agents cardiac MR imaging sequences. The main contribution of this work is to develop a new joint motion feature learning architecture to efficiently establish direct correspondences between motion features and tissue properties. This architecture consists of three seamless connected function layers: the heart localization layers can automatically crop the region of interest (ROI) sequences involving the left ventricle from the cardiac MR imaging sequences; the motion feature extraction layers, using long short-term memory-recurrent neural networks, a) builds patch-based motion features through local intensity changes between fixed-size patch sequences (cropped from image sequences), and b) uses optical flow techniques to build image-based features through global intensity changes between adjacent images to describe the motion of each pixel; the fully connected discriminative layers can combine two types of motion features together in each pixel and then build the correspondences between motion features and tissue identities (that is, infarct or not) in each pixel. We validated the performance of our framework in 165 cine cardiac MR imaging datasets by comparing to the ground truths manually segmented from delayed Gadolinium-enhanced MR cardiac images by two radiologists with more than 10 years of experience. Our experimental results show that our proposed method has a high and stable accuracy (pixel-level: 95.03%) and consistency (Kappa statistic: 0.91; Dice: 89.87%; RMSE: 0.72 mm; Hausdorff distance: 5.91 mm) compared to manual delineation results. Overall, the advantage of our framework is that it can determine the tissue identity in each pixel from its motion pattern captured by normal cine cardiac MR images, which makes it an attractive tool for the clinical diagnosis of infarction. (C) 2018 Elsevier B.V. All rights reserved.
基金:
National Key Research and Development Program of China [2016YFC 1300300]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [61771464, 61673020]; Shenzhen Research and Innovation [JCYJ 20170307165309009, JCYJ 20170413114916687, SGLH 20161212104605195]; Provincial Natural Science Research Program of the Higher Education Institutions of Anhui Province [KJ2016A016]; Anhui Provincial Natural Science FoundationNatural Science Foundation of Anhui Province [1708085 QF143]
语种:
外文
被引次数:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2017]版:
大类|2 区工程技术
小类|2 区计算机:人工智能2 区计算机:跨学科应用2 区工程:生物医学2 区核医学
最新[2025]版:
大类|1 区医学
小类|1 区计算机:人工智能1 区计算机:跨学科应用1 区工程:生物医学1 区核医学
JCR分区:
出版当年[2016]版:
Q1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ1COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCEQ1ENGINEERING, BIOMEDICALQ1COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS
最新[2023]版:
Q1COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCEQ1COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONSQ1ENGINEERING, BIOMEDICALQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构:[a]Department of Medical Imaging, Western University, London ON, Canada[b]School of Computer Science and Technology, Anhui University, Hefei, China
通讯作者:
通讯机构:[d]School of Biomedical Engineering, Sun Yat-Sen University, Shenzhen, China
推荐引用方式(GB/T 7714):
Chenchu Xu,Lei Xu,Zhifan Gao,et al.Direct delineation of myocardial infarction without contrast agents using a joint motion feature learning architecture[J].MEDICAL IMAGE ANALYSIS.2018,50:82-94.doi:10.1016/j.media.2018.09.001.
APA:
Chenchu Xu,Lei Xu,Zhifan Gao,Shen Zhao,Heye Zhang...&Shuo Li.(2018).Direct delineation of myocardial infarction without contrast agents using a joint motion feature learning architecture.MEDICAL IMAGE ANALYSIS,50,
MLA:
Chenchu Xu,et al."Direct delineation of myocardial infarction without contrast agents using a joint motion feature learning architecture".MEDICAL IMAGE ANALYSIS 50.(2018):82-94