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Direct delineation of myocardial infarction without contrast agents using a joint motion feature learning architecture

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收录情况: ◇ SCIE ◇ EI

机构: [a]Department of Medical Imaging, Western University, London ON, Canada [b]School of Computer Science and Technology, Anhui University, Hefei, China [c]Department of Medical Imaging, Beijing Anzhen Hospital, Capital Medical University, Beijing, China [d]School of Biomedical Engineering, Sun Yat-Sen University, Shenzhen, China [e]University 2020 Foundation, MA,USA [f]Department of Optical Engineering, Zhejiang University, Hangzhou, China
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关键词: Myocardial infarction Deep learning Motion feature Optical flow

摘要:
Changes in mechanical properties of myocardium caused by a infarction can lead to kinematic abnormalities. This phenomenon has inspired us to develop this work for delineation of myocardial infarction area directly from non-contrast agents cardiac MR imaging sequences. The main contribution of this work is to develop a new joint motion feature learning architecture to efficiently establish direct correspondences between motion features and tissue properties. This architecture consists of three seamless connected function layers: the heart localization layers can automatically crop the region of interest (ROI) sequences involving the left ventricle from the cardiac MR imaging sequences; the motion feature extraction layers, using long short-term memory-recurrent neural networks, a) builds patch-based motion features through local intensity changes between fixed-size patch sequences (cropped from image sequences), and b) uses optical flow techniques to build image-based features through global intensity changes between adjacent images to describe the motion of each pixel; the fully connected discriminative layers can combine two types of motion features together in each pixel and then build the correspondences between motion features and tissue identities (that is, infarct or not) in each pixel. We validated the performance of our framework in 165 cine cardiac MR imaging datasets by comparing to the ground truths manually segmented from delayed Gadolinium-enhanced MR cardiac images by two radiologists with more than 10 years of experience. Our experimental results show that our proposed method has a high and stable accuracy (pixel-level: 95.03%) and consistency (Kappa statistic: 0.91; Dice: 89.87%; RMSE: 0.72 mm; Hausdorff distance: 5.91 mm) compared to manual delineation results. Overall, the advantage of our framework is that it can determine the tissue identity in each pixel from its motion pattern captured by normal cine cardiac MR images, which makes it an attractive tool for the clinical diagnosis of infarction. (C) 2018 Elsevier B.V. All rights reserved.

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出版当年[2017]版:
大类 | 2 区 工程技术
小类 | 2 区 计算机:人工智能 2 区 计算机:跨学科应用 2 区 工程:生物医学 2 区 核医学
最新[2025]版:
大类 | 1 区 医学
小类 | 1 区 计算机:人工智能 1 区 计算机:跨学科应用 1 区 工程:生物医学 1 区 核医学
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出版当年[2016]版:
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Q1 ENGINEERING, BIOMEDICAL Q1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS
最新[2023]版:
Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Q1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS Q1 ENGINEERING, BIOMEDICAL Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

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第一作者机构: [a]Department of Medical Imaging, Western University, London ON, Canada [b]School of Computer Science and Technology, Anhui University, Hefei, China
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通讯机构: [d]School of Biomedical Engineering, Sun Yat-Sen University, Shenzhen, China
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