Clinical performance of antibodies to prothrombin and thrombin in Chinese patients with antiphospholipid syndrome: potential interest in discriminating patients with thrombotic events and non-thrombotic events
A hallmark feature of antiphospholipid syndrome (APS) is the presence of a wide spectrum of antiphospholipid antibodies. In this study, we evaluated the clinical relevance of antibodies to prothrombin (PT) (aPT) and thrombin (aThr) in Chinese patients with APS. A total of 229 subjects were tested, including 86 patients with APS [35 patients with primary APS (PAPS), 51 patients with APS associated with other diseases (APSAOD)], 104 patients with non-APS diseases (disease controls), and 39 healthy controls. Serum IgG/IgM/IgA aPT and aThr were determined by ELISA. The levels of both IgG/IgM/IgA aPT and IgG/IgM/IgA aThr were significantly increased in patients with PAPS and APSAOD compared with patients with non-APS thrombosis and non-APS PRM, and HC. Both IgG aPT and IgG aThr exhibited promising diagnostic potentials for APS with sensitivities and specificities of 16.3 and 95.8% (IgG aPT), and 19.8 and 99.3% (IgG aThr), respectively. Importantly, both IgG aPT (OR 4.06; 95% CI 1.49-11.05) and IgG aThr (OR 4.49; 95% CI 1.62-12.45) were significantly correlated with arterial, but not venous, thrombotic events. Our findings highlighted that IgG aPT and IgG aThr could serve as promising biomarkers to identify patients at risk of arterial thrombosis in China.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81373188, 81172857, 81302592]; Chinese National High Technology Research and Development Program, Ministry of Science and TechnologyNational High Technology Research and Development Program of China [2011AA02A113]; National Science Technology Pillar Program in the 12th Five-year Plan [2014BAI07B00]; Capital Health Research and Development of Special Grant [2014-1-4011]
第一作者机构：[1]Chinese Acad Med Sci, Dept Rheumatol & Clin Immunol, Peking Union Med Coll Hosp, 1 Shuai Fu Yuan, Beijing 100730, Peoples R China;[2]Peking Union Med Coll, Key Lab Rheumatol & Clin Immunol, Minist Educ, 1 Shuai Fu Yuan, Beijing 100730, Peoples R China;
通讯作者：
通讯机构：[1]Chinese Acad Med Sci, Dept Rheumatol & Clin Immunol, Peking Union Med Coll Hosp, 1 Shuai Fu Yuan, Beijing 100730, Peoples R China;[2]Peking Union Med Coll, Key Lab Rheumatol & Clin Immunol, Minist Educ, 1 Shuai Fu Yuan, Beijing 100730, Peoples R China;
推荐引用方式(GB/T 7714)：
Zhang Shulan,Wu Ziyan,Li Jing,et al.Clinical performance of antibodies to prothrombin and thrombin in Chinese patients with antiphospholipid syndrome: potential interest in discriminating patients with thrombotic events and non-thrombotic events[J].RHEUMATOLOGY INTERNATIONAL.2017,37(4):579-584.doi:10.1007/s00296-016-3594-0.
APA：
Zhang, Shulan,Wu, Ziyan,Li, Jing,Li, Ping,Chen, Si...&Li, Yongzhe.(2017).Clinical performance of antibodies to prothrombin and thrombin in Chinese patients with antiphospholipid syndrome: potential interest in discriminating patients with thrombotic events and non-thrombotic events.RHEUMATOLOGY INTERNATIONAL,37,(4)
MLA：
Zhang, Shulan,et al."Clinical performance of antibodies to prothrombin and thrombin in Chinese patients with antiphospholipid syndrome: potential interest in discriminating patients with thrombotic events and non-thrombotic events".RHEUMATOLOGY INTERNATIONAL 37..4(2017):579-584
