Background. Aortic dissection in pregnancy is a rare but lethal catastrophe. Clinical experiences are limited. We report our experience in 25 patients focusing on etiology, management strategies, and outcomes. Methods. Between June 1998 and February 2015, we treated 25 pregnant women (mean age, 31.6 +/- 4.7 years) in whom aortic dissection developed at a mean of 28 +/- 10 gestational weeks (GWs). Type A aortic dissection (TAAD) was present in 20 (80%) and type B (TBAD) in 5 (20%). Marfan syndrome was seen in 17 (68%). Management strategy was based on dissection type and GWs. Results. TAADs were managed surgically in 19 (95.0%) and medically in 1 (5.0%). Maternal and fetal mortalities were, respectively, 14.3% (1 of 7) and 0 (0 of 7) in the "delivery first" group (7 of 20), 16.7% (1 of 6) and 33.3% (2 of 6) in "single-stage delivery and aortic repair" group (6 of 20), 16.7% (1 of 6) and 66.7% (4 of 6) in "aortic repair first" group (6 of 20), and 100% (1 of 1) and 100% (1 of 1) in the "medical management" group (1 of 20). TBADs were managed surgically in 60% (3 of 5) and endovascularly and medically in 20% each (1 of 5). No maternal deaths occurred. Fetal mortality was 100% in the surgical group and 0% in the other groups. During late follow-up, which was complete in 95.2% (20 of 21), 3 maternal and 2 fetal deaths occurred in the TAAD group. Overall maternal survival was 68.6% at 5 years. Conclusions. Marfan syndrome predominates among women with aortic dissection in pregnancy. For TAADs, after 28 GWs, delivery followed by surgical repair can achieve maternal and fetal survival adequately; before 28 GWs, maternal survival should be prioritized given the high risk of fetal death. For TBADs in pregnancy, nonsurgical management is preferred.
基金:
National Key Technologies Research and Development ProgramNational Key Technology R&D Program [2015BA112B03]; Special Research Fund for Public Health and Welfare [201402009]
语种:
外文
被引次数:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2016]版:
大类|2 区医学
小类|2 区外科3 区心脏和心血管系统3 区呼吸系统
最新[2023]版:
大类|2 区医学
小类|2 区呼吸系统2 区外科3 区心脏和心血管系统
JCR分区:
出版当年[2015]版:
Q1SURGERYQ2CARDIAC & CARDIOVASCULAR SYSTEMSQ2RESPIRATORY SYSTEM
第一作者机构:[1]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Dept Cardiovasc Surg, Beijing, Peoples R China;[2]Beijing Engn Res Ctr Vasc Prostheses, Beijing, Peoples R China;[3]Chinese Acad Med Sci, Fu Wai Hosp, Beijing, Peoples R China;[4]Chinese Acad Med Sci, Cardiovasc Inst, Beijing, Peoples R China;[5]Yale Univ, Sch Med, Aort Inst Yale New Haven, New Haven, CT USA;[6]Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiovasc Surg, 2 Anzhen Rd, Beijing 100029, Peoples R China
通讯作者:
通讯机构:[1]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Dept Cardiovasc Surg, Beijing, Peoples R China;[2]Beijing Engn Res Ctr Vasc Prostheses, Beijing, Peoples R China;[3]Chinese Acad Med Sci, Fu Wai Hosp, Beijing, Peoples R China;[4]Chinese Acad Med Sci, Cardiovasc Inst, Beijing, Peoples R China;[5]Yale Univ, Sch Med, Aort Inst Yale New Haven, New Haven, CT USA;[6]Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiovasc Surg, 2 Anzhen Rd, Beijing 100029, Peoples R China
推荐引用方式(GB/T 7714):
Zhu Jun-Ming,Ma Wei-Guo,Peterss Sven,et al.Aortic Dissection in Pregnancy: Management Strategy and Outcomes[J].ANNALS OF THORACIC SURGERY.2017,103(4):1199-1206.doi:10.1016/j.athoracsur.2016.08.089.
APA:
Zhu, Jun-Ming,Ma, Wei-Guo,Peterss, Sven,Wang, Long-Fei,Qiao, Zhi-Yu...&Sun, Li-Zhong.(2017).Aortic Dissection in Pregnancy: Management Strategy and Outcomes.ANNALS OF THORACIC SURGERY,103,(4)
MLA:
Zhu, Jun-Ming,et al."Aortic Dissection in Pregnancy: Management Strategy and Outcomes".ANNALS OF THORACIC SURGERY 103..4(2017):1199-1206