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Aortic Dissection in Pregnancy: Management Strategy and Outcomes

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机构: [1]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Dept Cardiovasc Surg, Beijing, Peoples R China; [2]Beijing Engn Res Ctr Vasc Prostheses, Beijing, Peoples R China; [3]Chinese Acad Med Sci, Fu Wai Hosp, Beijing, Peoples R China; [4]Chinese Acad Med Sci, Cardiovasc Inst, Beijing, Peoples R China; [5]Yale Univ, Sch Med, Aort Inst Yale New Haven, New Haven, CT USA; [6]Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiovasc Surg, 2 Anzhen Rd, Beijing 100029, Peoples R China
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Background. Aortic dissection in pregnancy is a rare but lethal catastrophe. Clinical experiences are limited. We report our experience in 25 patients focusing on etiology, management strategies, and outcomes. Methods. Between June 1998 and February 2015, we treated 25 pregnant women (mean age, 31.6 +/- 4.7 years) in whom aortic dissection developed at a mean of 28 +/- 10 gestational weeks (GWs). Type A aortic dissection (TAAD) was present in 20 (80%) and type B (TBAD) in 5 (20%). Marfan syndrome was seen in 17 (68%). Management strategy was based on dissection type and GWs. Results. TAADs were managed surgically in 19 (95.0%) and medically in 1 (5.0%). Maternal and fetal mortalities were, respectively, 14.3% (1 of 7) and 0 (0 of 7) in the "delivery first" group (7 of 20), 16.7% (1 of 6) and 33.3% (2 of 6) in "single-stage delivery and aortic repair" group (6 of 20), 16.7% (1 of 6) and 66.7% (4 of 6) in "aortic repair first" group (6 of 20), and 100% (1 of 1) and 100% (1 of 1) in the "medical management" group (1 of 20). TBADs were managed surgically in 60% (3 of 5) and endovascularly and medically in 20% each (1 of 5). No maternal deaths occurred. Fetal mortality was 100% in the surgical group and 0% in the other groups. During late follow-up, which was complete in 95.2% (20 of 21), 3 maternal and 2 fetal deaths occurred in the TAAD group. Overall maternal survival was 68.6% at 5 years. Conclusions. Marfan syndrome predominates among women with aortic dissection in pregnancy. For TAADs, after 28 GWs, delivery followed by surgical repair can achieve maternal and fetal survival adequately; before 28 GWs, maternal survival should be prioritized given the high risk of fetal death. For TBADs in pregnancy, nonsurgical management is preferred.

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出版当年[2016]版:
大类 | 2 区 医学
小类 | 2 区 外科 3 区 心脏和心血管系统 3 区 呼吸系统
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 呼吸系统 2 区 外科 3 区 心脏和心血管系统
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出版当年[2015]版:
Q1 SURGERY Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Q2 RESPIRATORY SYSTEM
最新[2023]版:
Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Q1 RESPIRATORY SYSTEM Q1 SURGERY

影响因子: 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

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第一作者机构: [1]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Dept Cardiovasc Surg, Beijing, Peoples R China; [2]Beijing Engn Res Ctr Vasc Prostheses, Beijing, Peoples R China; [3]Chinese Acad Med Sci, Fu Wai Hosp, Beijing, Peoples R China; [4]Chinese Acad Med Sci, Cardiovasc Inst, Beijing, Peoples R China; [5]Yale Univ, Sch Med, Aort Inst Yale New Haven, New Haven, CT USA; [6]Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiovasc Surg, 2 Anzhen Rd, Beijing 100029, Peoples R China
通讯作者:
通讯机构: [1]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Dept Cardiovasc Surg, Beijing, Peoples R China; [2]Beijing Engn Res Ctr Vasc Prostheses, Beijing, Peoples R China; [3]Chinese Acad Med Sci, Fu Wai Hosp, Beijing, Peoples R China; [4]Chinese Acad Med Sci, Cardiovasc Inst, Beijing, Peoples R China; [5]Yale Univ, Sch Med, Aort Inst Yale New Haven, New Haven, CT USA; [6]Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiovasc Surg, 2 Anzhen Rd, Beijing 100029, Peoples R China
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