机构：[1]Chinese Acad Med Sci, Dept Rheumatol & Clin Immunol, Peking Union Med Coll Hosp, Beijing, Peoples R China;[2]Minist Educ, Key Lab Rheumatol & Clin Immunol, Peking Union Med Coll, Beijing, Peoples R China;[3]Capital Med Univ, Beijing Anzhen Hosp, Dept Clin Lab, Beijing, Peoples R China;医技科室检验科首都医科大学附属安贞医院[4]Fourth Mil Med Univ, Tangdu Hosp, Dept Blood Transfus, Xian, Peoples R China;[5]Jilin Univ, Dept Med Lab, Hosp 1, Changchun, Peoples R China
Single nucleotide polymorphisms (SNPs) in TNFSF4 and ANKRD55 genes have been shown to be associated with several autoimmune diseases, although whether these genes are susceptibility genes for dermatomyositis/polymyositis (DM/PM) has, to date, not been reported. This study aimed to investigate the potential associations of these SNPs with DM/PM in a Chinese Han population. Five SNPs in TNFSF4 (rs2205960, rs844644, and rs844648) and ANKRD55 (rs6859219, rs7731626) genes were genotyped using the SequenomMassArray system in 2297 Chinese individuals. In total, 1017 DM/PM patients and 1280 gender-matched healthy controls were genotyped. No significant associations were observed in DM/PM patients for the five SNPs analyzed. The association between SNPs and interstitial lung disease (ILD) was also investigated. Both DM-ILD (P-c = 0.030, OR = 0.65, 95% CI: 0.47-0.88) and DM/PM-ILD (P-c = 0.015, OR = 0.67, 95% CI: 0.51-0.87) exhibited a significant association with the rs7731626-A allele. Rs7731626-A was less frequently found in DM-ILD and DM/PM-ILD patients compared with healthy controls. This is the first study to demonstrate a positive association between ANKRD55 polymorphism and DM-ILD and DM/PM-ILD. A decreased frequency of rs7731626-A in DM-ILD and DM/PM-ILD patients suggests that the A variant may be protective against DM/PM-ILD.
基金：
Research Special Fund for Public Welfare Industry of Health [201202004]; National Natural Science Foundation of China GrantsNational Natural Science Foundation of China [81172857, 81373188]; Chinese National High Technology Research and Development Program, Ministry of Science and Technology Grants [2011AA02A113]; National Science Technology Pillar Program [2014BAI07B00]; Capital Health Research and Development of Special [2014-1-4011]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|3 区生物
小类|3 区生物工程与应用微生物4 区医学：研究与实验
最新[2023]版：
无
JCR分区：
出版当年[2015]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Chinese Acad Med Sci, Dept Rheumatol & Clin Immunol, Peking Union Med Coll Hosp, Beijing, Peoples R China;[2]Minist Educ, Key Lab Rheumatol & Clin Immunol, Peking Union Med Coll, Beijing, Peoples R China;
通讯作者：
通讯机构：[1]Chinese Acad Med Sci, Dept Rheumatol & Clin Immunol, Peking Union Med Coll Hosp, Beijing, Peoples R China;[2]Minist Educ, Key Lab Rheumatol & Clin Immunol, Peking Union Med Coll, Beijing, Peoples R China;
推荐引用方式(GB/T 7714)：
Li Liubing,Chen Si,Wen Xiaoting,et al.Positive Association between ANKRD55 Polymorphism 7731626 and Dermatomyositis/Polymyositis with Interstitial Lung Disease in Chinese Han Population[J].BIOMED RESEARCH INTERNATIONAL.2017,2017:-.doi:10.1155/2017/2905987.
APA：
Li, Liubing,Chen, Si,Wen, Xiaoting,Wang, Qian,Lv, Guanting...&Li, Yongzhe.(2017).Positive Association between ANKRD55 Polymorphism 7731626 and Dermatomyositis/Polymyositis with Interstitial Lung Disease in Chinese Han Population.BIOMED RESEARCH INTERNATIONAL,2017,
MLA：
Li, Liubing,et al."Positive Association between ANKRD55 Polymorphism 7731626 and Dermatomyositis/Polymyositis with Interstitial Lung Disease in Chinese Han Population".BIOMED RESEARCH INTERNATIONAL 2017.(2017):-
