国家自然科学基金(81470580)%北京市科技计划(Z141100002114025)%北京市教育委员会-首都医科大学心血管疾病精准医学北京实验室科研项目(PXM2015-014226-000028)National Natural Science Foundation of China(81470580)%Beijing Municipal Science and Technology Project(Z141100002114025)%Research Project of Beijing Laboratory of Cardiovascular Disease Precision Medicine,Capital Medical University,Beijing Municipal Education Committee(PXM2015-014226-000028)