Bicuspid aortic valve (BAV) is a common congenital heart disease. Our study was to analyze clinical features of BAV and evaluate whether aortic valve calcium score (AVCS) was a reliable marker for aortic stenosis (AS) in patients with BAV. 101 patients with BAV who both underwent echocardiology and cardiac computed tomography (CT) scan in our institution were included. Basic clinical data, haemodynamic feature, aortic valve and coronary calcium score were collected and compared among patients with different valve function and different degree of AS. Risk factors related to severe AS were evaluated by logistic regression, and a receiver operative characteristic curve was used to determine the cutoff calcium score greater than which the diagnosis of severe AS was optimized. Patients with aortic regurgitation (AR) were younger and demonstrated larger aortic annulus and sinus compared with patients with other valve dysfunction. Aortic valve calcium score was higher in patients with AS than with AR. For patients with different degree of AS, there were statistical significances in the value of age, aortic valve calcium score and coronary calcium score. AVCS was positively related to severe AS with an odd ratio of 1.286 (95 % CI 1.099-1.504) by every 300 points increase. AVCS was also a strong predictor for severe AS with area under the curve 0.855 with a cutoff value of 897 (sensitivity 86.7 %, specificity 72.2 %). Conclusively, aortic calcium score calculated by quantitative CT is a reliable marker in evaluating severity of AS.
基金：
Capital Special Project of Health Research and Development [2011-4003-01]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|3 区医学
小类|3 区核医学4 区心脏和心血管系统
最新[2023]版：
大类|4 区医学
小类|4 区心脏和心血管系统4 区核医学
JCR分区：
出版当年[2014]版：
Q2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ3CARDIAC & CARDIOVASCULAR SYSTEMS
最新[2023]版：
Q3CARDIAC & CARDIOVASCULAR SYSTEMSQ3RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[1]Chinese Acad Med Sci, Dept Radiol, State Key Lab Cardiovasc Dis, Fuwai Hosp,Natl Ctr Cardiovasc Dis, Beijing 100037, Peoples R China;[2]Peking Union Med Coll, Beijing 100037, Peoples R China;
通讯作者：
通讯机构：[1]Chinese Acad Med Sci, Dept Radiol, State Key Lab Cardiovasc Dis, Fuwai Hosp,Natl Ctr Cardiovasc Dis, Beijing 100037, Peoples R China;[2]Peking Union Med Coll, Beijing 100037, Peoples R China;
推荐引用方式(GB/T 7714)：
Ren Xinshuang,Zhang Minghui,Liu Kun,et al.The significance of aortic valve calcification in patients with bicuspid aortic valve disease[J].INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING.2016,32(3):471-478.doi:10.1007/s10554-015-0783-y.
APA：
Ren, Xinshuang,Zhang, Minghui,Liu, Kun,Hou, Zhihui,Gao, Yang...&Lu, Bin.(2016).The significance of aortic valve calcification in patients with bicuspid aortic valve disease.INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING,32,(3)
MLA：
Ren, Xinshuang,et al."The significance of aortic valve calcification in patients with bicuspid aortic valve disease".INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING 32..3(2016):471-478
