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Association between Body Mass Index and All-Cause Mortality in Hypertensive Adults: Results from the China Stroke Primary Prevention Trial (CSPPT)

Association between Body Mass Index and All-Cause Mortality in Hypertensive Adults: Results from the China Stroke Primary Prevention Trial (CSPPT)

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收录情况: ◇ SCIE

机构: [1]Peking Univ, Dept Cardiol, Hosp 1, Beijing 100034, Peoples R China; [2]Southern Med Univ, Natl Clin Res Ctr Kidney Dis, State Key Lab Organ Failure Res, Renal Div,Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China; [3]Anhui Med Univ, Inst Biomed, Hefei 230032, Peoples R China; [4]Chinese Acad Med Sci, State Key Lab Cardiovasc Dis, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Beijing 100037, Peoples R China; [5]Peking Union Med Coll, Beijing 100037, Peoples R China; [6]Capital Med Univ, Beijing Anzhen Hosp, Dept Epidemiol, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing 100029, Peoples R China
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关键词: obesity body mass index mortality hypertension China

摘要:
The association between elevated body mass index (BMI) and risk of death has been reported in many studies. However, the association between BMI and all-cause mortality for hypertensive Chinese adults remains unclear. We conducted a post-hoc analysis using data from the China Stroke Primary Prevention Trial (CSPPT). Cox regression analysis was performed to determine the significance of the association of BMI with all-cause mortality. During a mean follow-up duration of 4.5 years, 622 deaths (3.0%) occurred among the 20,694 participants aged 45-75 years. A reversed J-shaped relationship was observed between BMI and all-cause mortality. The hazard ratios (HRs) for underweight (<18.5 kg/m(2)), overweight (24.0-27.9 kg/m(2)), and obesity (28.0 kg/m(2)) were calculated relative to normal weight (18.5-23.9 kg/m(2)). The summary HRs were 1.56 (95% CI, 1.11-2.18) for underweight, 0.78 (95% CI 0.64-0.95) for overweight and 0.64 (95% CI, 0.48-0.85) for obesity. In sex-age-specific analyses, participants over 60 years of age had optimal BMI in the obesity classification and the results were consistent in both males and females. Relative to normal weight, underweight was associated with significantly higher mortality. Excessive weight was not associated with increased risk of mortality. Chinese hypertensive adults had the lowest mortality in grade 1 obesity.

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出版当年[2015]版:
大类 | 3 区 医学
小类 | 3 区 营养学
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 营养学
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出版当年[2014]版:
Q2 NUTRITION & DIETETICS
最新[2023]版:
Q1 NUTRITION & DIETETICS

影响因子: 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

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第一作者机构: [1]Peking Univ, Dept Cardiol, Hosp 1, Beijing 100034, Peoples R China;
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