Matrix metalloproteinases-2 (MMP-2) plays an important role in the pathogenesis of type A aortic dissection (AD). The aim of this study was to evaluate the association of 3 single nucleotide polymorphisms (SNPs) in the MMP-2 gene with type A AD risk and aortic diameters in patients. We performed a case-control study with 172 unrelated type A AD patients and 439 controls. Three SNPs rs11644561, rs11643630, and rs243865 were genotyped through the MassARRAY platform. Allelic associations of SNPs and SNP haplotypes with type A AD and aortic diameters in patients were evaluated. The frequency of the G allele of the rs11643630 polymorphism was significantly lower in type A AD patients than in control subjects (odds ratio 0.705, 95% confidence interval 0.545-0.912, P=0.008). The association remained significant after adjusting for clinical covariates (P=0.008). Carriers of the GG genotype of the rs11643630 polymorphism had significantly smaller aortic diameters than those with GT genotype or TT genotype (P=0.02). Further haplotype analysis identified 1 protective haplotype (GC; P=0.008) for development of type A AD. Again, a significant correlation was observed between haplotype GC and AD size (P=0.020). Our results suggest that MMP-2 gene polymorphisms contribute to type A AD susceptibility. In addition, MMP-2 gene SNPs are associated with AD size, which could be used as a target for the development of new drug therapy.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81470580, 91439127]; Beijing Municipal Administration of Hospitals' Youth Programme [QML2015115]
第一作者机构：[1]Capital Med Univ, Beijing Anzhen Hosp, Beijing Lab Cardiovasc Precis Med, Dept Cardiovasc Surg, Beijing 100029, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Anzhen Hosp, Beijing Lab Cardiovasc Precis Med, Dept Cardiovasc Surg, Beijing 100029, Peoples R China;
推荐引用方式(GB/T 7714)：
Liu Ou,Xie Wuxiang,Qin Yanwen,et al.MMP-2 gene polymorphisms are associated with type A aortic dissection and aortic diameters in patients[J].MEDICINE.2016,95(42):-.doi:10.1097/MD.0000000000005175.
APA：
Liu, Ou,Xie, Wuxiang,Qin, Yanwen,Jia, Lixin,Zhang, Jing...&Zhang, Hongjia.(2016).MMP-2 gene polymorphisms are associated with type A aortic dissection and aortic diameters in patients.MEDICINE,95,(42)
MLA：
Liu, Ou,et al."MMP-2 gene polymorphisms are associated with type A aortic dissection and aortic diameters in patients".MEDICINE 95..42(2016):-
