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ASSESSMENT OF RETROGRADE CORONARY VENOUS INFUSION OF MESENCHYMAL STEM CELLSCOMBINEDWITH BASIC FIBROBLASTGROWTH FACTOR IN CANINE MYOCARDIAL INFARCTION USING STRAIN VALUES DERIVED FROM SPECKLE-TRACKING ECHOCARDIOGRAPHY

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收录情况: ◇ SCIE ◇ EI

机构: [1]Capital Med Univ, Beijing AnZhen Hosp, Dept Ultrasound, Beijing 100029, Peoples R China; [2]Capital Med Univ, Beijing AnZhen Hosp, Emergency & Crit Care Ctr, Beijing 100029, Peoples R China; [3]Minist Educ, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing, Peoples R China; [4]Minist Educ, Key Lab Remodeling Related Cardiovasc Dis, Beijing, Peoples R China
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关键词: Retrograde coronary venous infusion Mesenchymal stem cells Canine Speckle-tracking echocardiography Strain analysis Acute myocardial infarction

摘要:
Speckle-tracking echocardiography was used to assess retrograde coronary venous infusion of mesenchymal stem cells (MSCs) combined with basic fibroblast growth factor (bFGF) in a canine model of acute myocardial infarction (AMI). AMI was induced by ligation of the left anterior descending coronary artery. Coronary venous retroperfusion was performed at 1 wk after AMI. Twenty-eight animals were randomized into four groups: saline, bFGF+saline, saline+MSCs and bFGF+MSCs. Echocardiography was performed before AMI, at 7 d post-AMI and 40 d after retroperfusion. Apoptotic cardiomyocytes in the border zone of the ischemic region were evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling. Vascular endothelial growth factor and factor VIII concentrations were measured by western blotting. The left ventricular end-systolic volume increased significantly, whereas the left ventricular ejection fraction and global and segmental strain values decreased significantly after AMI. After retroperfusion, the strain values of the infarct zone, but not conventional echocardiographic parameters, were significantly different between control and bFGF+MSC groups. Cardiomyocyte apoptosis decreased, whereas vascular endothelial growth factor and factor VIII concentrations were higher in the bFGF+MSC, bFGF and MSC groups. Cardiomyocyte apoptosis was well correlated with the strain values. Although retrograde coronary venous infusion of bFGF and MSCs promoted neo-vascularization of the infarcted myocardium and inhibited apoptosis, there was only a slight strain improvement without a substantial increase in global cardiac functions. (C) 2016 World Federation for Ultrasound in Medicine & Biology.

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出版当年[2015]版:
大类 | 3 区 医学
小类 | 2 区 声学 3 区 核医学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 声学 3 区 核医学
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出版当年[2014]版:
Q1 ACOUSTICS Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版:
Q2 ACOUSTICS Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子: 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

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第一作者机构: [1]Capital Med Univ, Beijing AnZhen Hosp, Dept Ultrasound, Beijing 100029, Peoples R China;
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通讯机构: [1]Capital Med Univ, Beijing AnZhen Hosp, Dept Ultrasound, Beijing 100029, Peoples R China;
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