The abnormal autophagy is associated with a variety of cardiovascular diseases. Long noncoding RNAs (lncRNAs) are emerging as new factors in gene regulation, but how lncRNAs operate in the regulation of autophagy in the heart is unclear. Here we report that a long noncoding RNA, named autophagy promoting factor (APF), can regulate autophagic cell death by targeting miR-188-3p and ATG7. The results show that miR-188-3p suppresses autophagy and myocardial infarction by targeting ATG7. Further, we find that APF lncRNA regulates miR-188-3p, and thus affects ATG7 expression, autophagic cell death and myocardial infarction. Our present study reveals a novel regulating model of autophagic programme, which comprises APF, miR-188-3p and ATG7 in the heart. Modulation of their levels may serve as potential targets and diagnostic tools for novel therapeutic strategies of myocardial infarction and heart failure.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81270160, 81470522, 81230005]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7142103]
第一作者机构：[1]Qingdao Univ, Coll Med, Inst Translat Med, Ctr Dev Cardiol, Qingdao 266021, Peoples R China;
通讯作者：
通讯机构：[1]Qingdao Univ, Coll Med, Inst Translat Med, Ctr Dev Cardiol, Qingdao 266021, Peoples R China;
推荐引用方式(GB/T 7714)：
Wang Kun,Liu Cui-Yun,Zhou Lu-Yu,et al.APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p[J].NATURE COMMUNICATIONS.2015,6:-.doi:10.1038/ncomms7779.
APA：
Wang, Kun,Liu, Cui-Yun,Zhou, Lu-Yu,Wang, Jian-Xun,Wang, Man...&Li, Pei-Feng.(2015).APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p.NATURE COMMUNICATIONS,6,
MLA：
Wang, Kun,et al."APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p".NATURE COMMUNICATIONS 6.(2015):-
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