机构:[1]Capital Med Univ, Natl Clin Res Ctr Cardiovasc Dis, Beijing, Peoples R China;[2]Capital Med Univ, Dept Cardiol, Beijing Anzhen Hosp, Beijing, Peoples R China临床科室心脏内科中心首都医科大学附属安贞医院
An abnormal corrected QT (QTc) interval is associated with the development of atrial fibrillation (AF). It is unclear whether QTc interval is a marker of arrhythmia recurrence after radiofrequency catheter ablation (RFCA) in patients with AF. This study sought to determine the relationship between abnormal QTc interval and the recurrence after RFCA in hypertensive patients with paroxysmal AF. Two hundred and forty-two hypertensive patients with paroxysmal AF who underwent first time RFCA were retrospectively evaluated. Baseline data and QTc before the procedure were collected. Ninety-eight patients had AF recurrence after a mean follow-up of 17.0 +/- 9.4 months. Those experiencing recurrence had a longer QTc interval than those without recurrence (429 +/- 26 vs. 419 +/- 23 ms, P = 0.004). Multivariate Cox regression analysis demonstrated the QTc interval and left atrial diameter (LAD) as independent predictors of AF recurrence. Patients with a long QTc interval were at an increased risk of AF recurrence (hazard ratio 2.757, 95% CI 1.661-4.611, P < 0.001) after adjustment for multiple factors. The QTc interval had an incremental value combined with the LAD in predicting AF recurrence after RFCA. The patients with a large LAD and a long QTc interval had a much higher AF recurrence rate compared with those with a small LAD and a non-long QTc interval (78 vs. 27%, P < 0.001). QTc interval prolongation is an independent risk factor for AF recurrence after RFCA in hypertensive patients. It provides a simple predictor for identifying the patients with hypertension likely to have AF recurrence after RFCA.
基金:
Beijing Municipal Administration of Hospitals, Clinical Medicine Development of SpecialFunding Support [ZY201302]; Chinaarrhythmia registration study (C-rhythm), Ministry of Science and Technology of China [2013BAI09B02]; International S&T Cooperation Program of China [2013DFB30310]; National Science Foundation of ChinaNational Natural Science Foundation of China [81370292, 81370290, 81470465]
第一作者机构:[1]Capital Med Univ, Natl Clin Res Ctr Cardiovasc Dis, Beijing, Peoples R China;[2]Capital Med Univ, Dept Cardiol, Beijing Anzhen Hosp, Beijing, Peoples R China
通讯作者:
通讯机构:[1]Capital Med Univ, Natl Clin Res Ctr Cardiovasc Dis, Beijing, Peoples R China;[2]Capital Med Univ, Dept Cardiol, Beijing Anzhen Hosp, Beijing, Peoples R China
推荐引用方式(GB/T 7714):
Liu Nian,Wen Song-Nan,Ruan Yan-Fei,et al.QTc interval prolongation predicts the ablation outcome in hypertensive patients with paroxysmal atrial fibrillation[J].EUROPEAN HEART JOURNAL SUPPLEMENTS.2015,17(B):B24-B38.doi:10.1093/eurheartj/suv017.
APA:
Liu, Nian,Wen, Song-Nan,Ruan, Yan-Fei,Zhang, Ting,Li, Song-Nan...&Ma, Chang-Sheng.(2015).QTc interval prolongation predicts the ablation outcome in hypertensive patients with paroxysmal atrial fibrillation.EUROPEAN HEART JOURNAL SUPPLEMENTS,17,(B)
MLA:
Liu, Nian,et al."QTc interval prolongation predicts the ablation outcome in hypertensive patients with paroxysmal atrial fibrillation".EUROPEAN HEART JOURNAL SUPPLEMENTS 17..B(2015):B24-B38