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Stem Cell Replacement Improves Expression of SMP30 in db/db Mice

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收录情况： ◇ SCIE

作者：

机构： [1]Kansai Med Univ, Dept Stem Cell Disorders, Hirakata, Osaka 5731010, Japan; [2]Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiac Surg, Beijing 100029, Peoples R China; [3]Kansai Med Univ, Dept Microbiol, Hirakata, Osaka 5731010, Japan; [4]Toyooka Hosp, Div Clin Pathol, Kobe, Hyogo 6688501, Japan

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关键词： SMP30 stem cell replacement cytokines fibrosis

摘要：

We have previously reported that replacing bone marrow stem cells may improve hyperglycemia and oxidative stress in db/db mice, a type 2 diabetic mouse model. Senescence marker protein 30 (SMP30) is an antioxidant protein that decreases with aging. However, it has not been clear whether SMP30 decreases in the livers of obese mice, and whether stem cell replacement would improve SMP30 expression in the liver. Bone marrow stem cells of db/db mice were replaced with the bone marrow stem cells of C57BL/6 mice. Plasma cytokine and insulin levels were measured, and glycogen content, expression of SMP30, and fibrosis in the liver were assessed. Our results showed that stem cell replacement increased the expression of SMP30 in the liver, resulting from decreased plasma inflammation cytokines and hyperinsulinemia in db/db mice. This is the first report that stem cell replacement increased the expression of SMP30 in the liver, and may help prevent fibrosis in the liver of db/db mice.

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出版当年[2014]版：

大类 | 3 区化学

小类 | 4 区化学综合

最新[2023]版：

大类 | 2 区生物学

小类 | 3 区生化与分子生物学 3 区化学：综合

JCR分区：

出版当年[2013]版：

Q2 CHEMISTRY, MULTIDISCIPLINARY

最新[2023]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 CHEMISTRY, MULTIDISCIPLINARY

影响因子： 4.9 最新[2023版] 5.6 最新五年平均 2.339 出版当年[2013版] 2.721 出版当年五年平均 2.464 出版前一年[2012版] 2.862 出版后一年[2014版]

第一作者：

第一作者机构： [1]Kansai Med Univ, Dept Stem Cell Disorders, Hirakata, Osaka 5731010, Japan;

通讯作者：

通讯机构： [1]Kansai Med Univ, Dept Stem Cell Disorders, Hirakata, Osaka 5731010, Japan;

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