The calcification initiation and progression of bioprosthetic heart valve were investigated in a rat model by enhanced micro-computed tomography, together with histologic study and scanning electron microscope analysis. The implantation data at early stage showed apparent dendritic patterns in the radiographic images for the glutaraldehyde-treated bovine pericardium and this dendritic pattern was verified to be associated with the vessel distribution in the tissue. Histologic study and scanning electron microscope analysis both indicated that the calcium deposits in the pericardium vessels regions were more grievous than those scattered in the collagen fibers in the first two weeks after implantation. Subsequently, calcification spreaded and the entire sample was severely calcified in 60 days. (C) 2014 Elsevier Ltd. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [10925208]; Chinese National Science & Technology support program in the twelfth five-year plan [2012BAI221301]
第一作者机构：[1]Chongqing Univ, Coll Mat Sci & Engn, Chongqing 400044, Peoples R China;
通讯作者：
通讯机构：[2]Chinese Natl Inst Food & Drug Control, Testing Dept Biomat & Tissue Engn Prod, Beijing 100050, Peoples R China;
推荐引用方式(GB/T 7714)：
Liu Jing,Zhong Shengping,Lan Hualin,et al.Mapping the calcification of bovine pericardium in rat model by enhanced micro-computed tomography[J].BIOMATERIALS.2014,35(29):8305-8311.doi:10.1016/j.biomaterials.2014.06.026.
APA：
Liu, Jing,Zhong, Shengping,Lan, Hualin,Meng, Xu,Zhang, Haibo...&Wang, Zhaoxu.(2014).Mapping the calcification of bovine pericardium in rat model by enhanced micro-computed tomography.BIOMATERIALS,35,(29)
MLA：
Liu, Jing,et al."Mapping the calcification of bovine pericardium in rat model by enhanced micro-computed tomography".BIOMATERIALS 35..29(2014):8305-8311
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