Role of leptin receptor gene polymorphisms in susceptibility to the development of essential hypertension: a case-control association study in a Northern Han Chinese population
In order to explore the potential association between the leptin receptor (LEPR) gene polymorphisms and essential hypertension (EH) risk in the Northern Han Chinese population, we recruited 823 hypertensive subjects and 491 healthy control subjects from the Northern Han Chinese. Genotyping was performed to identify the Lys109Arg, Gln223Arg and Lys656Asn polymorphisms of the LEPR gene. Significant associations were found in a dominant genetic model ([GG+AG] vs AA), P = 0.007, odds ratio (OR) = 3.697, 95% confidence interval (CI) 1.442-9.482), and in homozygote comparison (GG vs AA, P = 0.005, OR = 3.890, 95% CI 1.501-10.077) for the Gln223Arg polymorphism. No significant association could be found between Lys109Arg or Lys656Asn polymorphism and EH risk. Linkage disequilibrium was detected between the Lys109Arg and Gln223Arg polymorphisms, and haplotype analyses identified that the G-A haplotype was a protective haplotype for EH. Our studies demonstrated that the LEPR Gln223Arg polymorphism had an important role in a patient's susceptibility to EH in the Northern Han Chinese population.
基金：
National Institutes of Health (NIH)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [1R01-HL083218, 3R01-HL083218-01A2S1]; National High Technology Research and Development Program of ChinaNational High Technology Research and Development Program of China [2008AA02Z441]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7133232, 7120001, 7102045]
第一作者机构：[1]Capital Med Univ, Beijing Anzhen Hosp, Dept Hypertens Res, Beijing, Peoples R China;[2]Beijing Inst Heart Lung & Blood Vessel Dis, Beijing, Peoples R China;
通讯作者：
通讯机构：[6]Univ Illinois, Dept Med, Chicago, IL 60612 USA;[7]Univ Illinois, Cardiovasc Res Ctr, Chicago, IL 60612 USA;[8]Univ Illinois, Dept Med, 840 S Wood St,M-C 719, Chicago, IL 60612 USA
推荐引用方式(GB/T 7714)：
Liu Y.,Lou Y-Q,Liu K.,et al.Role of leptin receptor gene polymorphisms in susceptibility to the development of essential hypertension: a case-control association study in a Northern Han Chinese population[J].JOURNAL OF HUMAN HYPERTENSION.2014,28(9):551-556.doi:10.1038/jhh.2013.149.
APA：
Liu, Y.,Lou, Y-Q,Liu, K.,Liu, J-L,Wang, Z-G...&Xiao, L..(2014).Role of leptin receptor gene polymorphisms in susceptibility to the development of essential hypertension: a case-control association study in a Northern Han Chinese population.JOURNAL OF HUMAN HYPERTENSION,28,(9)
MLA：
Liu, Y.,et al."Role of leptin receptor gene polymorphisms in susceptibility to the development of essential hypertension: a case-control association study in a Northern Han Chinese population".JOURNAL OF HUMAN HYPERTENSION 28..9(2014):551-556
