Catheter Ablation of Asymptomatic Longstanding Persistent Atrial Fibrillation: Impact on Quality of Life, Exercise Performance, Arrhythmia Perception, and Arrhythmia-Free Survival
机构：[1]Univ Texas Austin, Texas Cardiac Arrhythmia Inst, St Davids Med Ctr, Austin, TX 78712 USA;[2]Univ Texas Austin, Coll Nat Sci, Austin, TX 78712 USA;[3]Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA;[4]Univ Foggia, Dept Cardiol, Foggia, Italy;[5]Montefiore Hosp, Albert Einstein Coll Med, New York, NY USA;[6]Capital Med Univ, Beijing Anzhen Hosp, Beijing, Peoples R China;首都医科大学附属安贞医院[7]Calif Pacific Med Ctr, San Francisco, CA USA;[8]Univ Roma Tor Vergata, Rome, Italy;[9]Stanford Univ, Div Cardiol, Palo Alto, CA 94304 USA;[10]Scripps Clin, San Diego, CA USA;[11]Case Western Reserve Univ, Cleveland, OH 44106 USA;[12]St Lukes Hosp, New York, NY USA;[13]3000 N I-35,Suite 720, Austin, TX 78705 USA
Ablation Outcome in Silent Longstanding Persistent AF BackgroundImpact of catheter ablation on exercise performance, quality of life (QoL) and symptom perception in asymptomatic longstanding persistent AF (LSP-AF) patients has not been reported yet. Methods and ResultsSixty-one consecutive patients (mean age 62 13 years, 71% males) with asymptomatic LSP-AF undergoing first catheter ablation were enrolled. Extended pulmonary vein antrum isolation plus ablation of complex fractionated atrial electrograms and nonpulmonary vein triggers was performed in all. QoL survey was taken at baseline and 12-months postablation, using Short Form-36 (SF-36). Information on arrhythmia perception was obtained using a standard questionnaire and corroborating symptoms with documented evidence of arrhythmia. Exercise tests were performed on 38 patients at baseline and 5 months after procedure. Recurrence was assessed using event recorder, cardiology evaluation, electrocardiogram, and 7-day holter monitoring. After 20 +/- 5 months follow-up, 36 (57%) patients remained recurrence-free off-AAD. Of the 25 patients experiencing recurrence, 21 (84%) were symptomatic. Compared to baseline, follow-up SF-36 scores improved significantly in many measures. For patients with successful ablation, physical component summary (PCS) and mental component summary (MCS) demonstrated substantial improvement (MCS: 64.2 +/- 22.3 to 70.1 +/- 18.6 [P = 0.041]; PCS: 62.6 +/- 18.4 to 70.0 +/- 14.4 [P = 0.032]). Postablation exercise study in recurrence-free patients showed significant reduction in resting and peak heart rate (75 +/- 11 vs. 90 +/- 17 and 132 +/- 20 vs. 154.5 +/- 36, respectively, P < 0.001), increase in peak oxygen pulse (13.4 +/- 3 vs. 18.9 +/- 16 mL/beat, 5.5 +/- 15, P = 0.001), peak VO2/kg (19.7 +/- 5 to 23.4 +/- 13 mL/kg/min [ 3.7 +/- 10, P = 0.043]), and corresponding MET (5.6 +/- 1 to 6.7 +/- 4 [1.1 +/- 3, P = 0.03]). No improvement was observed in patients with failed procedures. ConclusionSuccessful ablation improves exercise performance and QoL in asymptomatic LSP-AF patients.
基金：
Boston ScientificBoston Scientific; Biosense Webster; JanssenJohnson & Johnson USAJanssen Biotech Inc; St. Jude MedicalSt. Jude Medical; MedtronicMedtronic; Biotronik
通讯机构：[1]Univ Texas Austin, Texas Cardiac Arrhythmia Inst, St Davids Med Ctr, Austin, TX 78712 USA;[3]Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA;[7]Calif Pacific Med Ctr, San Francisco, CA USA;[9]Stanford Univ, Div Cardiol, Palo Alto, CA 94304 USA;[10]Scripps Clin, San Diego, CA USA;[11]Case Western Reserve Univ, Cleveland, OH 44106 USA;[12]St Lukes Hosp, New York, NY USA;[13]3000 N I-35,Suite 720, Austin, TX 78705 USA
推荐引用方式(GB/T 7714)：
Mohanty Sanghamitra,Santangeli Pasquale,Mohanty Prasant,et al.Catheter Ablation of Asymptomatic Longstanding Persistent Atrial Fibrillation: Impact on Quality of Life, Exercise Performance, Arrhythmia Perception, and Arrhythmia-Free Survival[J].JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY.2014,25(10):1057-1064.doi:10.1111/jce.12467.
APA：
Mohanty, Sanghamitra,Santangeli, Pasquale,Mohanty, Prasant,Di Biase, Luigi,Holcomb, Shawna...&Natale, Andrea.(2014).Catheter Ablation of Asymptomatic Longstanding Persistent Atrial Fibrillation: Impact on Quality of Life, Exercise Performance, Arrhythmia Perception, and Arrhythmia-Free Survival.JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY,25,(10)
MLA：
Mohanty, Sanghamitra,et al."Catheter Ablation of Asymptomatic Longstanding Persistent Atrial Fibrillation: Impact on Quality of Life, Exercise Performance, Arrhythmia Perception, and Arrhythmia-Free Survival".JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 25..10(2014):1057-1064
