Background: Several studies have reported that Connexin37 (Cx37) gene C1019T polymorphism is associated with myocardial infarction (MI) and coronary artery disease (CAD). However, the results remain contradictory. Methods and results: Pubmed, Embase, and Cochrane library databases were systemically searched. Data were extracted by two independent reviewers and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. A total of 3498 MI cases and 3986 controls, as well as 1808 CAD cases and 1197 controls were enrolled in this meta-analysis. For MI, the overall ORs and 95% CIs of 1019T were 1.04, 0.95-1.15; and 1.02, 0.85-1.22 in dominant and recessive models, respectively. For CAD, the overall ORs and 95% CIs of 1019T were 0.61, 0.51-0.72; and 0.52, 0.43-0.62 in dominant and recessive models, respectively. No publication bias was found in this meta-analysis. Conclusions: This meta-analysis showed that Cx37 C1019T was a risk factor for MI and a protective factor for CAD.