Computational fluid dynamics (CFD) is a widely used method in mechanical engineering to solve complex problems by analysing fluid flow, heat transfer, and associated phenomena by using computer simulations. In recent years, CFD has been increasingly used in biomedical research of coronary artery disease because of its high performance hardware and software. CFD techniques have been applied to study cardiovascular haemodynamics through simulation tools to predict the behaviour of circulatory blood flow in the human body. CFD simulation based on 3D luminal reconstructions can be used to analyse the local flow fields and flow profiling due to changes of coronary artery geometry, thus, identifying risk factors for development and progression of coronary artery disease. This review aims to provide an overview of the CFD applications in coronary artery disease, including biomechanics of atherosclerotic plaques, plaque progression and rupture; regional haemodynamics relative to plaque location and composition. A critical appraisal is given to a more recently developed application, fractional flow reserve based on CFD computation with regard to its diagnostic accuracy in the detection of haemodynamically significant coronary artery disease. (C) 2014 Elsevier Ltd. All rights reserved.
基金：
Natural Science Foundation of ChinaNational Natural Science Foundation of China [81271542]; grant for Excellent Talents from Beijing city [2011D003034000030]; grant for High Levels of Health Technical Personnel in Beijing City Health System [2013-3-011]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2013]版：
大类|4 区医学
小类|4 区工程：生物医学4 区核医学
最新[2023]版：
大类|2 区医学
小类|2 区工程：生物医学2 区核医学
JCR分区：
出版当年[2012]版：
Q2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2ENGINEERING, BIOMEDICAL
最新[2023]版：
Q1ENGINEERING, BIOMEDICALQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[1]Curtin Univ, Dept Imaging & Appl Phys, Discipline Med Imaging, Perth, WA 6845, Australia;
通讯作者：
通讯机构：[2]Capital Med Univ, Beijing Anzhen Hosp, Dept Radiol, Beijing 100029, Peoples R China;[3]Capital Med Univ, Beijing Anzhen Hosp, Dept Radiol, 2 Anzhen Rd, Beijing 100029, Peoples R China
推荐引用方式(GB/T 7714)：
Sun Zhonghua,Xu Lei.Computational fluid dynamics in coronary artery disease[J].COMPUTERIZED MEDICAL IMAGING AND GRAPHICS.2014,38(8):651-663.doi:10.1016/j.compmedimag.2014.09.002.
APA：
Sun, Zhonghua&Xu, Lei.(2014).Computational fluid dynamics in coronary artery disease.COMPUTERIZED MEDICAL IMAGING AND GRAPHICS,38,(8)
MLA：
Sun, Zhonghua,et al."Computational fluid dynamics in coronary artery disease".COMPUTERIZED MEDICAL IMAGING AND GRAPHICS 38..8(2014):651-663
