详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Sodium current disorders: Geneticist's view

文献详情

资源类型：

作者：

机构： [a]Molecular Cardiology, IRCCS, Fondazione Salvatore Maugeri, Via Maugeri 10, Pavia, 27100, Italy [b]Department of Molecular Medicine, University of Pavia, Via Maugeri 10, Pavia, 27100, Italy [c]Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University, 2 Anzhen Road, Beijing, 100029, China [d]Cardiovascular Genetics, Leon Charney Division of Cardiology, New York University, 522 First Avenue, New York, NY 10016, United States

出处：

DOI：

ISSN：

关键词： Genetics Ion channel Sodium

摘要：

Cardiac sodium channel is responsible for pulse generation and conduction in the heart. Rapid progression in molecular genetics has greatly enlarged the field of sodium current disorders. Identification of the underlying genetic variants has improved understanding of the pathophysiologic mechanism. Genetic tests allow physicians to diagnose concealed/borderline cases, perform risk stratification, and select gene-specific and/or mutation-specific therapies. Appropriate selection of the candidates for genetic screening is essential to optimizing the cost/benefit ratio. © 2014 Elsevier Inc.

语种：

第一作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Congenital long QT syndrome type 3 [2]Prognostic value of ion channel genes in Chinese patients with gliomas based on mRNA expression profiling [3]Co-expression of mouse TMEM63A, TMEM63B and TMEM63C confers hyperosmolarity activated ion currents in HEK293 cells [4]Identification of small-molecule ion channel modulators in C. elegans channelopathy models [5]A three ion channel genes-based signature predicts prognosis of primary glioblastoma patients and reveals a chemotherapy sensitive subtype [6]癫痫的发病机制研究进展 [7]K+-dependent paradoxical membrane depolarization and Na+ overload, major and reversible contributors to weakness by ion channel leaks [8]Evolving Molecular Genetics of Glioblastoma [9]钾离子通道β亚单位KCNE4对KCNQ1及HERG电流的影响 [10]机械敏感性离子通道Piezo1在免疫细胞和胰腺炎中的研究进展