机构：[a]Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院中心实验室[b]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China神经科系统神经内科首都医科大学宣武医院[c]Beijing Geriatric Medical Research Center, Beijing, China[d]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China[e]National Clinical Research Center for Geriatric Disorders, Beijing, China
Subjective cognitive decline (SCD) is a risk factor for Alzheimer's disease (AD). Urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) has been identified as a biomarker for AD. It was hypothesized that if urinary AD7c-NTP were also elevated in SCD, as it is in prodromal AD (mild cognitive impairment stage), it could be a convenient and efficient clinical biomarker for the early diagnosis of SCD. SCD is often accompanied by a depressive state (DS), and the impact of DS on urinary AD7c-NTP levels remains unknown. A total of 297 right-handed Chinese Han subjects were recruited, including 98 subjects with SCD, 92 patients with DS, and 107 well-matched cognitively normal controls (NC). The levels of AD7c-NTP in urine samples were measured using an enzyme-linked immunosorbent assay AD7c-NTP kit. Our results demonstrated that urinary AD7c-NTP levels in the SCD group (0.7561±0.5657 ng/mL) were not significantly higher than in either the DS (0.7527±0.5607 ng/mL) or NC (0.7214±0.5077 ng/mL) groups. Furthermore, urinary AD7c-NTP levels were not correlated with Hamilton Depression Rating Scale and Hamilton Anxiety Scale scores, but they were negatively associated with Mini-Mental State Examination scores (r = -0.222, p = 0.033) and Montreal Cognitive Assessment-Basic scores (r = -0.207, p = 0.048). Urinary AD7c-NTP level is not elevated in SCD and is unaffected by DS. Urinary AD7c-NTP may therefore not be a good potential biomarker for SCD and DS, although it may become elevated with more severe cognitive decline.
基金：
National Key Research and Development Program of China [2016YFC1306300, 2016YFC0103000, 2018YFA0108503]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [61633018, 81801052, 81522021, 81430037, 81471731]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201706]; Beijing Nature Science FoundationBeijing Natural Science Foundation [7161009]; Beijing Municipal Commission of Health and Family Planning [PXM2019_026283_000002]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M641414]; Beijing Postdoctoral Research FoundationChina Postdoctoral Science Foundation [ZZ2019-12]
第一作者机构：[a]Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China[b]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China
通讯作者：
通讯机构：[a]Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China[b]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China[c]Beijing Geriatric Medical Research Center, Beijing, China[d]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China[e]National Clinical Research Center for Geriatric Disorders, Beijing, China[*1]No.45, Changchun Street, Beijing 100053, P.R. China.
推荐引用方式(GB/T 7714)：
Yuxia Li,Meimei Kang,Hongxing Wang,et al.Urinary Alzheimer-Associated Neuronal Thread Protein is not Elevated in Patients with Subjective Cognitive Decline and Patients with Depressive State.[J].JOURNAL OF ALZHEIMERS DISEASE.2019,71(4):1115-1123.doi:10.3233/JAD-190401.
APA：
Yuxia Li,Meimei Kang,Hongxing Wang,He Jin,Xiaozhen Wang...&Ying Han.(2019).Urinary Alzheimer-Associated Neuronal Thread Protein is not Elevated in Patients with Subjective Cognitive Decline and Patients with Depressive State..JOURNAL OF ALZHEIMERS DISEASE,71,(4)
MLA：
Yuxia Li,et al."Urinary Alzheimer-Associated Neuronal Thread Protein is not Elevated in Patients with Subjective Cognitive Decline and Patients with Depressive State.".JOURNAL OF ALZHEIMERS DISEASE 71..4(2019):1115-1123
