Hydroxyapatite (HAP) has been used in clinic, but its disadvantages such as low strength, poor toughness and not easy to form are still restricted to its wide application. In order to prepare the ideal and suitable for clinical application of nano-spiced hydroxyapatite, this paper does not add any dispersants and surfactants in conditions with sodium phosphate and calcium nitrate as raw material, sodium hydroxide adjust pH value, using the orthogonal experimental design to optimize the preparation technology for precipitation in the needle HAP. The results show that the effect of reaction conditions on HAP crystal morphology was temperature>drop acceleration>pH. When pH=9, the reaction temperature is 90 ℃ and the dropping speed of 2 mL/min for the optimal solution, the rules can be prepared traits, uniform particle size, high crystallinity, tends to the needle-shaped nano-hydroxyapatite powder. Reaction temperature can improve the crystallization rate of HAP, increase the size of the HAP crystals, tend to be more acicular crystal shape, but when the temperature is too high for the promotion of long axis gradually less than short axis, makes the increase of the length to diameter ratio trend slowed. The decrease of the drop acceleration can improve the crystallization degree of the product, which is beneficial to the formation of the acicular hydroxyapatite. Although the increase of pH can accelerate the formation of crystal nucleus, the crystallization rate and product purity of the product can be improved, but it is not conducive to the growth of grain, and the high pH can slow the formation of needle. © 2018, Chinese Ceramic Society. All right reserved.