To investigate the changes of mitochondrion by transferring antisense oligodeoxynucleotide Stat3 into laryngeal carcinoma Hep-2 cell, for elucidating the mechanism of laryngeal carcinoma Hep-2 cell apoptosis, for developing more effective treatment for laryngeal cancer. The designed Stat3 ASODN was transferred into laryngeal carcinoma Hep-2 cell by lipofection. Mitochondrion membrane potential, VDAC and Cyt-c were detected for determining the changes of mitochondrion. MMP was fell, Cyt-c and VDAC were increased with the heighten concentration of ASODN. Mitochondria approach play an important role in the apoptosis mechanism of human Hep-2 cell by Stat3. This research elucidated the regulating mechanism of Hep-2 cell proliferation by Stat3, provided a new research focus for clinical therapy.
语种：
外文
PubmedID：
第一作者：
第一作者机构：[1]首都医科大学宣武医院耳鼻咽喉一头颈外科(北京，100053)
通讯作者：
通讯机构：[1]首都医科大学宣武医院耳鼻咽喉一头颈外科(北京，100053)
推荐引用方式(GB/T 7714)：
吕海丽,张秋航,严波.[Mitochondrial mechanisms of antisense oligodeoxynucleotide Stat3 induced apoptosis in laryngeal carcinoma cell].[J].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery.2012,26(7):316-8.
APA：
吕海丽,张秋航&严波.(2012).[Mitochondrial mechanisms of antisense oligodeoxynucleotide Stat3 induced apoptosis in laryngeal carcinoma cell]..Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery,26,(7)
MLA：
吕海丽,et al."[Mitochondrial mechanisms of antisense oligodeoxynucleotide Stat3 induced apoptosis in laryngeal carcinoma cell].".Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 26..7(2012):316-8
