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Exploration of 16 candidate genes identifies the association of IDE with Alzheimer's disease in Han Chinese.

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机构： [a]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, China [b]Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China [c]Department of Neurology, Hua Shan Hospital, Fudan University, Shanghai, China [d]Department of Geriatrics, Guangzhou Brain Hospital, Affiliated Hospital of Guangzhou, Medical College, Guangzhou, China

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Alzheimer's disease (AD) has a complex pattern of inheritance and many genes have recently been reported to contribute to the disease susceptibility. We selected 106 SNPs within 16 candidate genes and performed a multistage association study using 4 sample sets consisting of 731 AD patients and 738 control subjects to identify genetic factors for AD in Han Chinese. A single nucleotide polymorphism (SNP) in the insulin degrading enzyme gene (IDE), rs3781239, showed a significant association with AD. The C allele increased the risk of AD 1.72-fold than the G allele (odds ratio [OR] = 1.72, 95% confidence interval [CI] = 1.17-2.53, p = 0.006) and CC carriers had a 4.89-fold higher risk for AD than that of the carriers with CG and GG genotypes (odds ratio = 4.89, 95% CI = 1.85-12.91, p = 0.001). Moreover, the CC genotype was significantly associated with earlier age at onset (p = 0.001, hazard ratio [HR] = 2.09, 95% CI = 1.38-3.18). Our data suggest that the polymorphism of IDE is associated with susceptibility to Alzheimer's disease in Han Chinese. Copyright Â© 2012 Elsevier Inc. All rights reserved.

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出版当年[2011]版：

大类 | 2 区医学

小类 | 2 区老年医学 2 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区老年医学 3 区神经科学

第一作者：

第一作者机构： [a]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, China

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通讯机构： [a]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, China [b]Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China [*1]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing 100053, China. [*2]Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China.

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