Aim: To analyze the association between adiponectin gene exon 2 Gly15Gly (T45G)polymorphisms and metabolic syndrome. Methods: A total of 156 subjects in hypertensive clinic of Xuanwu Hospital, Capital University of Medical Sciences who had all the metabolic syndrome compositions and 133 corresponding healthy controls who had body examination at the same time were involved. They all singed the informed consent. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to determine the genotype of adiponectin gene Gly15Gly in the two groups. Frequencies of genotype and allele were compared. The difference in the frequencies of genotype and allele was analyzed in different age and different sex. Results: A total 156 in the metabolic syndrome group and 133 in the normal control group were undertaken to the amplification of objective gene, no drop-out. 1 Comparison of genotype and allele frequency in the two groups: The frequencies of TT, TG and GG genotypes were 51.9%, 39.8% and 8.3% in the normal control group, 46.8%, 42.3% and 10.9% in the metabolic syndrome group, respectively. There was no significant difference between the two groups (P > 0.05). The frequencies of T and G allele were 61.8% and 28.2% in the normal control group, 67.9% and 32.1% metabolic syndrome group. There was no significant difference between the two groups (P > 0.05). 2 Comparison of genotype and allele in different sexes and different ages in the two groups; There was no significant difference after grouping based on age and sex (P > 0.05). Conclusion: There may be no significant correlation between adiponectin exon 2 Gly15Gly polymorphism and metabolic syndrome.
语种:
外文
第一作者:
第一作者机构:[1]首都医科大学宣武医院心血管内科,北京市 lO0053
通讯机构:[1]首都医科大学宣武医院心血管内科,北京市 lO0053
推荐引用方式(GB/T 7714):
刘东霞,华琦,郭金成,et al.Difference of adiponectin gene exon 2 Gly15Gly genotype and allele frequency between patients with metabolic syndrome and normal persons[J].Chinese Journal of Clinical Rehabilitation.2006,10(36):
APA:
刘东霞,华琦,郭金成,刘荣坤&杨峥.(2006).Difference of adiponectin gene exon 2 Gly15Gly genotype and allele frequency between patients with metabolic syndrome and normal persons.Chinese Journal of Clinical Rehabilitation,10,(36)
MLA:
刘东霞,et al."Difference of adiponectin gene exon 2 Gly15Gly genotype and allele frequency between patients with metabolic syndrome and normal persons".Chinese Journal of Clinical Rehabilitation 10..36(2006)