机构：[1]Department of Neurology, Xuanwu Hospital, Capital University of Medical Science, Beijing, 100053, China神经科系统神经内科首都医科大学宣武医院
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摘要：
OBJECTIVE: To assess the association between NAD(P)H: quinone oxidoreductase 1 (NQO1) C609 T allele and apolipoprotein E (ApoE) polymorphism and sporadic Alzheimer disease (SAD). METHODS: The polymorphisms of NQO1 and ApoE gene were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 92 SAD patients and 108 normal controls, all of Han nationality. RESULTS: The frequencies of mutant T allele and T/C + T/T genotype at nucleotide position 609 of NQO1 gene were 56% and 89% respectively in the patients with SAD, significantly higher than those in the controls (45% and 71% respectively) with an odds ratio of 1.56 (for mutant T allele) and of 3.301 (for genotype) respectively. The frequency of the ApoE2 allele was significantly lower in the SAD patients than in the controls (chi(2) = 3.753, P < 0.05) and the frequency of ApoE4 was higher in the SAD patients, however, without a statistically significant difference (chi(2) = 1.863, P = 0.172). No significant interaction was found between NQO1 C609T and ApoE polymorphisms in SAD patients. CONCLUSION: NQO1 C609T may be an independent genetic risk factor for SAD in Chinese.
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外文
第一作者：
第一作者机构：[1]Department of Neurology, Xuanwu Hospital, Capital University of Medical Science, Beijing, 100053, China
推荐引用方式(GB/T 7714)：
Ma Q.L,Yang J.F,Shao M,et al.Association between NAD(P)H: quinone oxidoreductase and apolipoprotein E gene polymorphisms in Alzheimer's disease[J].Zhonghua yi xue za zhi.2003,83(24):
APA：
Ma, Q.L,Yang, J.F,Shao, M,Dong, X.M&Chen, B.(2003).Association between NAD(P)H: quinone oxidoreductase and apolipoprotein E gene polymorphisms in Alzheimer's disease.Zhonghua yi xue za zhi,83,(24)
MLA：
Ma, Q.L,et al."Association between NAD(P)H: quinone oxidoreductase and apolipoprotein E gene polymorphisms in Alzheimer's disease".Zhonghua yi xue za zhi 83..24(2003)
