AIM: The neuroprotective action of APP17-mer peptide for glutamate toxicity was preliminarily confirmed by observing the effect of APP17-mer peptide and glutamate on growth of SY5Y neuroblastoma cells and expression of NT-3 and NF. METHODS: Measurement of MTT metabolic rate, LDH leakage rate and cell count, Western blot examination of SY5Y expression of NT3 and NF. RESULTS: Glutamate reduced MTT metabolic rate, cell count and expression of NT-3 and NF, but increased LDH leakage rate. The addition of APP17-mer peptide almost or fully normalized the foregoing indicators. CONCLUSION: Glutamate is neurotoxic, and APP17-mer peptide can reduce this damage, and is neuroprotective.
语种：
外文
第一作者：
第一作者机构：[1]首都医科大学宣武医院北京脑老化研究实验室,北京100053
推荐引用方式(GB/T 7714)：
王 蓉,张景艳,艾厚喜,et al.Effect of APP17-mer peptide on glutamate neurotoxicity[J].Chinese Pharmacological Bulletin.2000,16(3):
APA：
王 蓉,张景艳,艾厚喜,姬志娟&盛树力.(2000).Effect of APP17-mer peptide on glutamate neurotoxicity.Chinese Pharmacological Bulletin,16,(3)
MLA：
王 蓉,et al."Effect of APP17-mer peptide on glutamate neurotoxicity".Chinese Pharmacological Bulletin 16..3(2000)
