To observe the anti-dementia effect of Bushenjiannao 1 decoction on mice.
The learning and memory tests were realized with a water maze on the learning and memory impact of mice induced by scopolamine and cycloheximide. The effect of Bushenjiannao 1 decoction on the independent activity and anti-fatigue ability of mice were also investigated.
Bushenjiannao 1 decoction used at a medium dose of 15 g crude drug/kg and a higher dose of 45 g crude drug/kg could significantly improve the learning and memory abilities of mice injected with scopolamine. Higher doses could improve these abilities of mice injected with cycloheximide, and also improve the anti-fatigue ability of mice. No significant differences were observed in the independent activity of mice between the groups.
Bushenjiannao 1 decoction helps improve the learning and memory abilities and enhance the anti-fatigue ability, but has no effect on excitability of the central nervous system.
语种：
外文
PubmedID：
第一作者：
第一作者机构：[1]首都医科大学宣武医院北京市脑老化重点实验室，100053
推荐引用方式(GB/T 7714)：
李斌,李林,张丽,et al.[Effect of bushenjiannao 1 decoction on learning and memory functions and anti-fatigue ability in mice].[J].Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.1999,24(2):104-6, 127.
APA：
李斌,李林,张丽,陈铁钰,李宗信...&李文.(1999).[Effect of bushenjiannao 1 decoction on learning and memory functions and anti-fatigue ability in mice]..Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,24,(2)
MLA：
李斌,et al."[Effect of bushenjiannao 1 decoction on learning and memory functions and anti-fatigue ability in mice].".Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 24..2(1999):104-6, 127
