机构：[1]Beijing Univ Chinese Med, Beijing, Peoples R China;[2]China Acad Chinese Mec Sci, Xiyuan Hosp, Beijing, Peoples R China;[3]Capital Med Univ, Beijing, Peoples R China;[4]Capital Med Univ, Beijing Anzhen Hosp, Beijing, Peoples R China;首都医科大学附属安贞医院[5]Shantou Univ, Med Coll, Shantou, Guangdong, Peoples R China;[6]Guangdong Gen Hosp, Guangdong Geriatr Inst, Dept Rehabil Med, Guangzhou, Guangdong, Peoples R China;研究所广东省老年医学研究所广东省人民医院[7]Guangdong Acad Med Sci, Guangzhou, Guangdong, Peoples R China;广东省人民医院[8]Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China
Background: Osteoporosis is an important health problem worldwide. Siwu decoction (SWD) and its modification have a good clinical effect on osteoporosis. However, the molecular mechanism of SWD on osteoporosis has not been thoroughly explained. Material/Methods: A systematic pharmacological methodology was utilized to predict the active compounds and potential targets of SWD, collect the genes of osteoporosis and the known targets of SWD, and analyze the osteoporosis and SWD's network. Results: Five networks were constructed and analyzed: (1) Osteoporosis genes' protein-protein interaction (PPI) network; (2) Compound-compound target network of SWD; (3) SWD-osteoporosis PPI network; (4) Compound-known target network of SWD; and (5) SWD known target-osteoporosis PPI network. Several osteoporosis and treatment-related targets (eg.,. HSP90ABI, FGFR1, HRAS, GRB2, and PGF), clusters, biological processes, and signaling pathways (e.g., PI3K-Akt signaling pathway, insulin signaling pathway, MAPK signaling pathway and FoxO signaling pathway) were found. Conclusions: The therapeutic effect of SWD on osteoporosis may be achieved by interfering with the biological processes and signaling pathways related to the development of osteoporosis.
基金：
Dominant Disease Project of China Academy of Chinese Medical Sciences [CACMSO7Y004]
第一作者机构：[1]Beijing Univ Chinese Med, Beijing, Peoples R China;[2]China Acad Chinese Mec Sci, Xiyuan Hosp, Beijing, Peoples R China;
通讯作者：
通讯机构：[2]China Acad Chinese Mec Sci, Xiyuan Hosp, Beijing, Peoples R China;[8]Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China
推荐引用方式(GB/T 7714)：
Bao Tingting,Yang Kailin,Long Zhiyong,et al.Systematic Pharmacological Methodology to Explore the Pharmacological Mechanism of Siwu Decoction for Osteoporosis[J].MEDICAL SCIENCE MONITOR.2019,25:8152-8171.doi:10.12659/MSM.917393.
APA：
Bao, Tingting,Yang, Kailin,Long, Zhiyong,Zeng, Liuting&Li, Yuehua.(2019).Systematic Pharmacological Methodology to Explore the Pharmacological Mechanism of Siwu Decoction for Osteoporosis.MEDICAL SCIENCE MONITOR,25,
MLA：
Bao, Tingting,et al."Systematic Pharmacological Methodology to Explore the Pharmacological Mechanism of Siwu Decoction for Osteoporosis".MEDICAL SCIENCE MONITOR 25.(2019):8152-8171
