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Transcranial direct current stimulation reduces seizure frequency in patients with refractory focal epilepsy: A randomized, double-blind, sham-controlled, and three-arm parallel multicenter study

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Dongju Yang[a,b] * ; Qun Wang[b,c,d,e] ; Cuiping Xu[f] ; Fang Fang[g] ; Jingjing Fan[c] ; Liping Li[a,b] ; Qiaoyi Du[a,b] ; Ruihua Zhang[h] ; Ye Wang[a,b] ; Yicong Lin[a,b] ; Zhaoyang Huang[a,b] ; HongmeiWang[g] ; Chunhong Chen[g] ; Qinlan Xu[c] ; YueWang[c] ; Yi Zhang[g] ; Zhang Zhang[a,b] ; Xin Zhao[a,b] ; Xuan Zhao[i] ; Ting Li[i] ; Chunyan Liu[a,b,j] ; Yulian Niu[a,b] ; Qihui Zhou[a,b] ; Qilin Zhou[a,b] ; Yiran Duan[a,b] ; Xiao Liu[c] ; Tingting Yu[c] ; Qing Xue[a,b] ; Jing Li[a,b] ; Xiaona Dai[a,b] ; Jiaqi Han[a,b] ; Changhong Ren[g] ; Huini Xu[g] ; Na Li[g] ; Jishui Zhang[k] ; Na Xu[h] ; Kun Yang[l] ; Yuping Wang[a,b,e] ;
机构： [a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [b]Beijing Key Laboratory of Neuromodulation, Beijing, China [c]Department of Neurology, Beijing Tiantan Hosipital, Capital Medical University, Beijing, China [d]China National Clinical Research Center for Neurological Diseases, Beijing, 100070, China [e]Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China [f]Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [g]Department of Neurology, Beijing Children's Hospital, Capital Medical University, Beijing, China [h]Department of Geriatric Medicine, Beijing Luhe Hospital, Affiliated to Capital Medical University, China [i]Department of Pediatric, Xuanwu Hospital, Capital Medical University, Beijing, China [j]Department of Neurology, Beijing Luhe Hospital, Affiliated to Capital Medical University, China [k]Department of Mental Health, Beijing Children's Hospital, Capital Medical University, Beijing, China [l]Department of Evidence-Based Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China
出处：
DOI： 10.1016/j.brs.2019.09.006
ISSN：

关键词： Interval between sessions Refractory focal epilepsy Repeated sessions Transcranial direct current stimulation (tDCS)

摘要：
Background: Transcranial direct current stimulation (tDCS) has been explored in epilepsy with limited samples, varied parameters, and inconclusive results. We aimed to study the efficacy of tDCS for patients with refractory focal epilepsy. Method: We conducted a randomized, double-blind, sham-controlled, and three-arm (Group 1 (sham), Group 2 (20-min), and Group 3 (2 × 20-min)) tDCS parallel multicenter study. The primary outcome measurement was seizure frequencies (SFs). The study consisted of 28-days baseline, 14-days treatment, and 56-days follow-up. The cathode was placed over the epileptogenic focus, and the current intensity was 2 mA. The generalized estimating equations model, one-way analysis of variance, chi-square and Kruskal-Wallis test were used for analysis. Results: Of the 82 enrolled patients, 70 patients were included for final analysis (Group 1, n = 21; Group 2, n = 24; and Group 3, n = 25). There was a significant reduction in SFs for both active tDCS groups compared with the sham group. Patients in Group 2 showed a significantly 50.73–21.91% greater reduction in SFs that lasted for 4 weeks (p = 0.008–0.060). Patients in Group 3 showed a significantly 63.19–49.79% greater reduction in SFs compared with the sham group that lasted for 5 weeks (p = 0.011–0.045). Patients in Group 3 had a 64.98–66.32% greater reduction in SFs at W9–W10, when compared with Group 2 (p = 0.021–0.022). Conclusion: Fourteen consecutive days tDCS significantly decreased SFs in patients with refractory focal epilepsy, with 2 × 20-min daily stimulation protocol being superior to 20-min daily stimulation protocol. © 2019

基金：
国家自然科学基金
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 神经科学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 临床神经病学 1 区 神经科学
JCR分区：
出版当年[2018]版：
Q1 NEUROSCIENCES Q1 CLINICAL NEUROLOGY
最新[2023]版：
Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [b]Beijing Key Laboratory of Neuromodulation, Beijing, China
通讯作者：
通讯机构： [a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [b]Beijing Key Laboratory of Neuromodulation, Beijing, China [e]Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Dongju Yang,Qun Wang,Cuiping Xu,et al.Transcranial direct current stimulation reduces seizure frequency in patients with refractory focal epilepsy: A randomized, double-blind, sham-controlled, and three-arm parallel multicenter study[J].BRAIN STIMULATION.2020,13(1):109-116.doi:10.1016/j.brs.2019.09.006.
APA：
Dongju Yang,Qun Wang,Cuiping Xu,Fang Fang,Jingjing Fan...&Yuping Wang.(2020).Transcranial direct current stimulation reduces seizure frequency in patients with refractory focal epilepsy: A randomized, double-blind, sham-controlled, and three-arm parallel multicenter study.BRAIN STIMULATION,13,(1)
MLA：
Dongju Yang,et al."Transcranial direct current stimulation reduces seizure frequency in patients with refractory focal epilepsy: A randomized, double-blind, sham-controlled, and three-arm parallel multicenter study".BRAIN STIMULATION 13..1(2020):109-116

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