详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Cell swelling, softening and invasion in a three-dimensional breast cancer model

文献详情

资源类型：

WOS体系：

收录情况： ◇ SCIE ◇ EI ◇ 自然指数

作者：

机构： [1]Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. [2]Department of Physics, University of Ottawa, Ottawa, Ontario, Canada. [3]Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA, USA. [4]School of Systems Science, Beijing Normal University, Beijing, China. [5]Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China. [6]Xuanwu Hospital, Capital Medical University, Beijing, China. [7]Harvard T. H. Chan School of Public Health, Boston, MA, USA

出处：

DOI：

ISSN：

摘要：

Control of the structure and function of three-dimensional multicellular tissues depends critically on the spatial and temporal coordination of cellular physical properties, yet the organizational principles that govern these events and their disruption in disease remain poorly understood. Using a multicellular mammary cancer organoid model, we map here the spatial and temporal evolution of positions, motions and physical characteristics of individual cells in three dimensions. Compared with cells in the organoid core, cells at the organoid periphery and the invasive front are found to be systematically softer, larger and more dynamic. These mechanical changes are shown to arise from supracellular fluid flow through gap junctions, the suppression of which delays the transition to an invasive phenotype. These findings highlight the role of spatiotemporal coordination of cellular physical properties in tissue organization and disease progression. © 2019, The Author(s), under exclusive licence to Springer Nature Limited.

语种：

高被引：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2019]版：

大类 | 1 区

物理

小类 | 1 区物理：综合

最新[2023]版：

大类 | 1 区

物理与天体物理

小类 | 1 区物理：综合

JCR分区：

出版当年[2018]版：

Q1 PHYSICS, MULTIDISCIPLINARY

最新[2023]版：

Q1 PHYSICS, MULTIDISCIPLINARY

影响因子： 18.1 最新[2023版] 19.5 最新五年平均 20.113 出版当年[2018版] 21.797 出版当年五年平均 22.727 出版前一年[2017版] 19.256 出版后一年[2019版]

第一作者：

第一作者机构： [1]Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

通讯作者：

通讯机构： [1]Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

推荐引用方式(GB/T 7714)：

APA：

MLA：

Cell swelling, softening and invasion in a three-dimensional breast cancer model $(function () { $("[data-toggle='tooltip']").tooltip(); });

文献详情

Cell swelling, softening and invasion in a three-dimensional breast cancer model