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Simultaneous PET-MRI imaging of cerebral blood flow and glucose metabolism in the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease

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收录情况： ◇ SCIE

作者：
Bixiao Cui[1] * ; Tianhao Zhang[2,3] * ; Yan Ma[4] ; Zhongwei Chen[5] ; Jie Ma[1] ; Lei Ma[1] ; Liqun Jiao[4] ; Yun Zhou[6] ; Baoci Shan[2,3,7] ; Jie Lu[1,8] ;
机构： [1]Department of Nuclear Medicine, Xuanwu Hospital Capital Medical University, Beijing, China [2]Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China [3]School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, China [4]Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China [5]GE Healthcare, Beijing, China [6]Mallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA [7]CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, China [8]Department of Radiology, Xuanwu Hospital Capital Medical University, Beijing, China
出处：
DOI： 10.1007/s00259-019-04551-w
ISSN：

关键词： Cerebral blood flow Glucose metabolism Ischaemic cerebrovascular disease PET/MR Superficial temporal artery-middle cerebral artery bypass

摘要：
Purpose: Cerebral blood flow (CBF) and glucose metabolism are important and significant factors in ischaemic cerebrovascular disease. The objective of this study was to use quantitative hybrid PET/MR to evaluate the effects of surgery treatment on the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease. Methods: Fifteen patients diagnosed with ischaemic cerebrovascular disease were evaluated using a hybrid TOF PET/MR system (Signa, GE Healthcare). The CBF value measured by arterial spin labelling (ASL) and the standardized uptake value ratio (SUVR) measured by 18F-FDG PET were obtained, except for the infarct area and its contralateral side, before and after bypass surgery. The asymmetry index (AI) was calculated from the CBF and SUVR of the ipsilateral and contralateral cerebral hemispheres, respectively. The ΔCBF and ΔSUVR were calculated as the percent changes of CBF and SUVR between before and after surgery, and paired t tests were used to determine whether a significant change occurred. Spearman’s rank correlation was also used to compare CBF with glucose metabolism in the same region. Results: The analysis primarily revealed that after bypass surgery, a statistically significant increase occurred in the CBF on the affected side (P < 0.01). The postprocedural SUVR was not significantly higher than the preprocedural SUVR (P > 0.05). However, the postprocedural AI values for CBF and SUVR were significantly lower after surgery than before surgery (P < 0.01). A significant correlation was found between the AI values for preoperative CBF and SUVR on the ipsilateral hemisphere (P < 0.01). Conclusions: The present study demonstrates that a combination of ASL and 18F-FDG PET could be used to simultaneously analyse changes in patients’ cerebral haemodynamic patterns and metabolism between before and after superficial temporal artery-middle cerebral artery (STA-MCA) bypass surgery. This therefore represents an essential tool for the evaluation of critical haemodynamic and metabolic status in patients with symptomatic unilateral ischaemic cerebrovascular disease. © 2019, The Author(s).

基金：
This work was funded through grants from the National Natural Science Foundation of China (Grant No. 81671662) and the Beijing Municipal Administration of Hospitals’ Ascent Plan (Grant No. DFL20180802).
语种：
外文
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中科院(CAS)分区：
出版当年[2019]版：
大类 | 1 区 医学
小类 | 1 区 核医学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 核医学
JCR分区：
出版当年[2018]版：
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Department of Nuclear Medicine, Xuanwu Hospital Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Nuclear Medicine, Xuanwu Hospital Capital Medical University, Beijing, China [2]Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China [3]School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, China [7]CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, China [8]Department of Radiology, Xuanwu Hospital Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Bixiao Cui,Tianhao Zhang,Yan Ma,et al.Simultaneous PET-MRI imaging of cerebral blood flow and glucose metabolism in the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease[J].EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING.2020,47(7):1668-1677.doi:10.1007/s00259-019-04551-w.
APA：
Bixiao Cui,Tianhao Zhang,Yan Ma,Zhongwei Chen,Jie Ma...&Jie Lu.(2020).Simultaneous PET-MRI imaging of cerebral blood flow and glucose metabolism in the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,47,(7)
MLA：
Bixiao Cui,et al."Simultaneous PET-MRI imaging of cerebral blood flow and glucose metabolism in the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease".EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 47..7(2020):1668-1677

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