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Blood-brain barrier disruption may contribute to white matter lesions in the setting of internal jugular venous stenosis.

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收录情况： ◇ SCIE

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机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, P.R. China [2]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, P.R. China [3]Department of Neurology, Beijing Ditan Hospital, Capital Medical University, Beijing, P.R. China [4]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA [5]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, P.R. China

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Cloudy white matter lesions are associated imaging features of internal jugular venous stenosis（IJVS）. However, the mechanism of the IJVS associated white matter lesions is still unclear. This study aims to evaluate blood-brain barrier integrity of the patients with IJVS. A total of 45 eligible patients with internal jugular venous stenosis confirmed by contrast-MRV and 45 healthy controls were enrolled into this study. The levels of serum MMP-9 and the markers of tight junctions, including occludin and ZO-1 obtained from IJVS patients and control group were tested by enzyme-linked immune-sorbent assay and compared. Both the levels of serum MMP-9 (0.2ng/ml) and occludin (0.05ng/ml) in IJVS group were higher than in the control group (0.01ng/ml vs 0 ng/ml, all p<0.001 ). While, the levels of serum ZO-1 showed no statistical significance between the two groups (0.55ng/ml vs 0.735ng/ml, P=0.34). The levels of serum MMP-9 between the subset with or without white matter lesions in IJVS group showed a significant difference (0.22 [0.06, 0.43] vs. 0.01 [0.01, 0.06], P =0.019). BBB disruption may participate in the formation of IJVS-associated white matter lesions; the mechanism of BBB disruption may involve MMP-9. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

JCR分区：

出版当年[2017]版：

Q4 CLINICAL NEUROLOGY Q4 NEUROSCIENCES

最新[2023]版：

Q3 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 2 最新[2023版] 2 最新五年平均 1.716 出版当年[2017版] 2.051 出版当年五年平均 2.298 出版前一年[2016版] 1.811 出版后一年[2018版]

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第一作者机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, P.R. China

通讯作者：

通讯机构： [2]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, P.R. China [5]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, P.R. China

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