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The correlation of fractional anisotropy parameters with Ki-67 index, and the clinical implication in grading of non-enhancing gliomas and neuronal-glial tumors.

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收录情况： ◇ SCIE

作者：

机构： [a]Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, USA [b]Department of Pathology, University of Rochester Medical Center, Rochester, NY, USA [c]Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA [d]Department of Neurosurgery, Beijing Tiantan Hospital, Beijing, China [e]Clinical and Translational Research and Public Health Sciences, University of Rochester Medical Center, Rochester, NY, USA [f]Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA [g]Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY, USA

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摘要：

To investigate the correlation between the FA parameters and Ki-67 labeling index, and their diagnostic performance in grading supratentorial non-enhancing gliomas and neuronal-glial tumors (GNGT). This institutional review board-approved, Health Insurance Portability and Accountability (HIPAA) compliant retrospective study enrolled 35 patients, including 19 with low grade GNGT and 16 with high grade GNGT. The mean FA, maximal FA and mean maximal FA values derived from diffusion tensor imaging were measured. The correlation between the FA parameters and the Ki-67 labeling index was assessed by Spearman rank test. The receiver operating characteristic curve analysis and multivariate logistic regression analysis were performed to detect the optimal imaging parameters in grading GNGT. The three FA parameters of low grade GNGT were significantly lower than the high grade GNGT (p < 0.001). The mean FA, maximal FA and mean maximal FA had significant positive correlation with Ki-67 labeling index (p = 0.001, p < 0.001, p < 0.001 respectively). The maximal FA showed a higher sensitivity and specificity in grading of non-enhancing GNGT with specificity of 78.9%, sensitivity of 100.0%, respectively. The FA parameters correlated with Ki-67 labeling index, and were useful surrogates in preoperative grading supratentorial non-enhancing GNGT. Copyright © 2019 Elsevier Inc. All rights reserved.

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中科院(CAS)分区：

出版当年[2019]版：

大类 | 4 区医学

小类 | 3 区核医学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区核医学

JCR分区：

出版当年[2018]版：

Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

最新[2023]版：

Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 2.1 最新[2023版] 2.3 最新五年平均 2.112 出版当年[2018版] 2.349 出版当年五年平均 2.564 出版前一年[2017版] 2.053 出版后一年[2019版]

第一作者：

第一作者机构： [a]Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, USA [*1]Department of Imaging Sciences, University of Rochester Medical Center, 601 Elmwood Avenue, PO Box 648, Rochester, NY 14642- 8638, USA.

通讯作者：

通讯机构： [a]Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, USA [*1]Department of Imaging Sciences, University of Rochester Medical Center, 601 Elmwood Avenue, PO Box 648, Rochester, NY 14642- 8638, USA.

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