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Association between p.R4810K Variant and Postoperative Collateral Formation in Patients with Moyamoya Disease

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资源类型：

收录情况： ◇ SCIE

作者：
Peicong Ge[a,b,c,d,e] * ; Xun Ye[a,b,c,d,e] ; Xingju Liu[a,b,c,d,e] ; Xiaofeng Deng[a,b,c,d,e] ; Jia Wang[a,b,c,d,e] ; Rong Wang[a,b,c,d,e] ; Yan Zhang[a,b,c,d,e] ; Dong Zhang[a,b,c,d,e] ; Qian Zhang[a,b,c,d,e] ; Jizong Zhao[a,b,c,d,e,f,*1] ;
机构： [a]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [b]China National Clinical Research Center for Neurological Diseases, Beijing, China [c]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China [d]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China [e]Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China [f]Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China
出处：
DOI： 10.1159/000503250
ISSN：

关键词： Digital subtraction angiography Moyamoya disease p R4810K variant Postoperative collateral formation Surgical revascularization

摘要：
Object: To investigate the association between p.R4810K variant and postoperative collateral formation (PCF) in patients with moyamoya disease. Methods: The p.R4810K variant was detected in 254 Chinese moyamoya patients. Surgically treated 273 hemispheres with preoperative and postoperative digital subtraction angiography were included. PCF was evaluated on lateral and anteroposterior views using angiography. Univariate and multivariate logistic regression analyses were performed to determine the influence factors for PCF. Results: Among 254 patients, 191 (75.2%) patients carried wild-type p.R4810K variant (GG) and 63 patients (24.8%) carried the heterozygous p.R4810K variant (GA). PCF was better in patients with GA than in patients with GG both on lateral views and anteroposterior views (p < 0.001 and p < 0.001). Over the median 7 months follow-up after discharge, good PCF was observed in 201 hemispheres (73.6%), and poor PCF was observed in 72 hemispheres (26.4%). The univariable logistic regression showed that patients with GA (OR 4.681; 95% CI 1.925-11.383; p = 0.001) was associated with good PCF. On the other hand, the increasing age (OR 0.971; 95% CI 0.952-0.989; p = 0.002) and the presence of hemorrhage (OR 0.189; 95% CI 0.096-0.374; p = 0.000) were associated with poor PCF. Multivariate logistic regression analyses of p.R4810K variant and clinical variables showed that GA (OR 3.671; 95% CI 1.452-9.283; p = 0.006) was associated with a good PCF, while the presence of hemorrhage (OR 0.258; 95% CI 0.065-0.362; p = 0.000) was identified as a predictor of poor PCF. Conclusions: The heterozygous p.R4810K variant was associated with better PCF. © 2019 S. Karger AG, Basel. All rights reserved.

语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 3 区 医学
小类 | 3 区 临床神经病学 3 区 外周血管病
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 外周血管病 4 区 临床神经病学
JCR分区：
出版当年[2017]版：
Q2 CLINICAL NEUROLOGY Q2 PERIPHERAL VASCULAR DISEASE
最新[2023]版：
Q3 CLINICAL NEUROLOGY Q3 PERIPHERAL VASCULAR DISEASE

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [a]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [b]China National Clinical Research Center for Neurological Diseases, Beijing, China [c]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China [d]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China [e]Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China
通讯作者：
通讯机构： [a]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [b]China National Clinical Research Center for Neurological Diseases, Beijing, China [c]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China [d]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China [e]Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China [f]Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China [*1]Department of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing 100070 (China)
推荐引用方式(GB/T 7714)：
Peicong Ge,Xun Ye,Xingju Liu,et al.Association between p.R4810K Variant and Postoperative Collateral Formation in Patients with Moyamoya Disease[J].CEREBROVASCULAR DISEASES.2019,48(1-2):77-84.doi:10.1159/000503250.
APA：
Peicong Ge,Xun Ye,Xingju Liu,Xiaofeng Deng,Jia Wang...&Jizong Zhao.(2019).Association between p.R4810K Variant and Postoperative Collateral Formation in Patients with Moyamoya Disease.CEREBROVASCULAR DISEASES,48,(1-2)
MLA：
Peicong Ge,et al."Association between p.R4810K Variant and Postoperative Collateral Formation in Patients with Moyamoya Disease".CEREBROVASCULAR DISEASES 48..1-2(2019):77-84

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